PMID- 23818925
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130703
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of 
      Breast Cancer Cells by Inhibiting Akt/mTOR Signaling, and Its Apoptotic Effects 
      Are Enhanced by Autophagy Inhibition.
PG  - 385219
LID - 10.1155/2013/385219 [doi]
LID - 385219
AB  - Anthricin (deoxypodophyllotoxin) is a natural product isolated from Anthriscus 
      sylvestris (L.) Hoffm. (Apiaceae). Here, we investigated the effect of anthricin 
      on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer 
      actions in breast cancer cells. Many studies have supported the contention that 
      the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably 
      deregulated in breast cancer and that autophagy plays important roles in the 
      development of this type of cancer, although the exact underlying mechanisms 
      remain unknown. Our data confirmed that anthricin markedly induced apoptosis in 2 
      breast cancer cell lines, MCF7 (estrogen receptor positive) and MDA-MB-231 
      (estrogen receptor, progesterone receptor, and Her2/Neu receptor negative). 
      Anthricin treatment decreased the levels of phosphorylated Akt and mTORC1, 
      followed by inhibition of cell growth. Interestingly, blockage of autophagy by a 
      pharmacological inhibitor or genetic deletion of ULK1 and Atg13 accelerated 
      anthricin-induced apoptosis, suggesting that autophagy has cytoprotective 
      effects. Taken together, our results indicate that anthricin is an inhibitor of 
      mTOR and that a combination of an autophagy inhibitor and anthricin may serve as 
      a new promising strategy for the treatment of breast cancer cells.
FAU - Jung, Chang Hwa
AU  - Jung CH
AD  - Department of Food Biotechnology, University of Science and Technology, Daejon 
      305-806, Republic of Korea ; Division of Metabolism and Functionality Research, 
      Korea Food Research Institute, 1201 Anyangpangyo-ro, Seongnam 463-746, Republic 
      of Korea.
FAU - Kim, Heemun
AU  - Kim H
FAU - Ahn, Jiyun
AU  - Ahn J
FAU - Jung, Sung Keun
AU  - Jung SK
FAU - Um, Min Young
AU  - Um MY
FAU - Son, Kun-Ho
AU  - Son KH
FAU - Kim, Tae Wan
AU  - Kim TW
FAU - Ha, Tae Youl
AU  - Ha TY
LA  - eng
PT  - Journal Article
DEP - 20130529
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3681310
EDAT- 2013/07/03 06:00
MHDA- 2013/07/03 06:01
PMCR- 2013/05/29
CRDT- 2013/07/03 06:00
PHST- 2013/03/05 00:00 [received]
PHST- 2013/05/08 00:00 [revised]
PHST- 2013/05/08 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/07/03 06:01 [medline]
PHST- 2013/05/29 00:00 [pmc-release]
AID - 10.1155/2013/385219 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:385219. doi: 10.1155/2013/385219. 
      Epub 2013 May 29.