PMID- 23819639
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20211021
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 8
DP  - 2013 Jul 2
TI  - The association between XPC Lys939Gln gene polymorphism and urinary bladder 
      cancer susceptibility: a systematic review and meta-analysis.
PG  - 112
LID - 10.1186/1746-1596-8-112 [doi]
AB  - BACKGROUND: Numerous epidemiological studies have been conducted to explore the 
      association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C 
      (XPC) gene and urinary bladder cancer susceptibility. However, the results remain 
      inconclusive. In order to derive a more precise estimation of this relationship, 
      a large and update meta-analysis was performed in this study. METHODS: A 
      comprehensive search was conducted through researching MEDLINE, EMBASE, PubMed, 
      Web of Science, China Biomedical Literature database (CBM) and China National 
      Knowledge Infrastructure (CNKI) databases before June 2013. Crude odds ratios 
      (ORs) with 95% confidence intervals (CIs) were calculated to estimate the 
      strength of the association. RESULTS: A total of 12 studies with 4828 cases and 
      4890 controls for evaluating the XPC Lys939Gln polymorphism and urinary bladder 
      cancer were included. Overall, there was significant associations between the XPC 
      Lys939Gln polymorphism and urinary bladder cancer risk were found for homozygous 
      model (OR = 1.352, 95% CL = 1.088-1.681), heterozygous model (OR = 1.354, 95% 
      CL = 1.085-1.688), and allele comparison (OR = 1.109, 95% CL = 1.013-1.214). In 
      subgroup analysis by ethnicity and source of controls, there were still 
      significant associations detected in some genetic models. CONCLUSION: Our 
      meta-analysis suggested that the XPC Lys939Gln polymorphism contributed to the 
      risk of urinary bladder cancer. VIRTUAL SLIDES: The virtual slide(s) for this 
      article can be found here: 
      http://www.diagnosticpathology.diagnomx.eu/vs/1001118393101798.
FAU - Dou, Kun
AU  - Dou K
AD  - Department of Urology, Kunming General Hospital of Chengdu Military Command, 
      Kunming 650032, China. kundou_km@163.com
FAU - Xu, Qingzhu
AU  - Xu Q
FAU - Han, Xiaolu
AU  - Han X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20130702
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (DNA-Binding Proteins)
RN  - 156533-34-5 (XPC protein, human)
SB  - IM
MH  - DNA-Binding Proteins/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic/*genetics
MH  - Urinary Bladder Neoplasms/*genetics
MH  - Xeroderma Pigmentosum/*genetics
PMC - PMC3744163
EDAT- 2013/07/04 06:00
MHDA- 2013/11/19 06:00
PMCR- 2013/07/02
CRDT- 2013/07/04 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/06/18 00:00 [accepted]
PHST- 2013/07/04 06:00 [entrez]
PHST- 2013/07/04 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
PHST- 2013/07/02 00:00 [pmc-release]
AID - 1746-1596-8-112 [pii]
AID - 10.1186/1746-1596-8-112 [doi]
PST - epublish
SO  - Diagn Pathol. 2013 Jul 2;8:112. doi: 10.1186/1746-1596-8-112.