PMID- 23819839
OWN - NLM
STAT- MEDLINE
DCOM- 20140618
LR  - 20140122
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 92
IP  - 1
DP  - 2014 Feb
TI  - Prediction of retinal pigment epithelial tear in serous vascularized pigment 
      epithelium detachment.
PG  - e50-6
LID - 10.1111/aos.12234 [doi]
AB  - PURPOSE: The aim of the study was to identify predictive factors for detection of 
      impending retinal pigment epithelium (RPE) tears in patients under anti-VEGF 
      therapy for treatment of retinal pigment epithelial detachment (PED) due to 
      exudative age-related macular degeneration (AMD) using near-infrared reflectance 
      imaging (NIR), spectral-domain optical coherence tomography (SD-OCT) and 
      fluorescein angiography (FLA). METHODS: We retrospectively evaluated NIR, SD-OCT 
      and FLA images, number of intravitreal injections as well as demographical data 
      of 103 eyes of 98 patients with vascularized PED [48.5% fibrovascular PED (fPED), 
      51.5% serous vascularized PED (svPED)] secondary to AMD. RESULTS: Fifteen eyes 
      with svPED of 103 included eyes (14.6%) developed an RPE tear under anti-VEGF 
      therapy. Prior to RPE tear formation, we could identify radial hyperreflective 
      lines spreading in a funnel-like pattern across the PED lesion in NIR images in 
      11 eyes correlating with folds in the RPE on corresponding SD-OCT scans (mean 
      observation period: 115.4 +/- 66.6 days; mean number of injections: 3.2 +/- 1.5; mean 
      PED height 828.2 +/- 356.5 mum). In nine RPE tears (81.8%), the edge of the tear 
      could be clearly localized on the opposite side of the PED lesion in relation to 
      the origin of hyperreflective lines. None of the fPED patients showed the 
      described signal. CONCLUSIONS: Patients under anti-VEGF therapy for treatment of 
      svPED due to AMD frequently show radial hyperreflective lines in NIR images prior 
      to RPE tear development that correspond to wrinkled changes in the RPE. 
      Hyperreflective lines may serve as an indicator for an impending RPE tear in 
      svPED patients.
CI  - (c) 2013 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Clemens, Christoph R
AU  - Clemens CR
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      GermanyDepartment of Ophthalmology, University of Bonn Medical Center, Bonn, 
      Germany.
FAU - Bastian, Nina
AU  - Bastian N
FAU - Alten, Florian
AU  - Alten F
FAU - Milojcic, Carolin
AU  - Milojcic C
FAU - Heiduschka, Peter
AU  - Heiduschka P
FAU - Eter, Nicole
AU  - Eter N
LA  - eng
PT  - Journal Article
DEP - 20130702
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Infrared Rays
MH  - Intravitreal Injections
MH  - Male
MH  - Neovascularization, Pathologic/*diagnosis
MH  - Ophthalmoscopy
MH  - Retinal Detachment/*diagnosis/etiology
MH  - Retinal Perforations/*diagnosis
MH  - Retinal Pigment Epithelium/*blood supply
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
MH  - Wet Macular Degeneration/*complications/drug therapy
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - near-infrared
OT  - optical coherence tomography
OT  - pigment epithelium detachment
OT  - pigment epithelium tear
EDAT- 2013/07/04 06:00
MHDA- 2014/06/19 06:00
CRDT- 2013/07/04 06:00
PHST- 2013/07/04 06:00 [entrez]
PHST- 2013/07/04 06:00 [pubmed]
PHST- 2014/06/19 06:00 [medline]
AID - 10.1111/aos.12234 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2014 Feb;92(1):e50-6. doi: 10.1111/aos.12234. Epub 2013 Jul 2.