PMID- 23821300
OWN - NLM
STAT- MEDLINE
DCOM- 20140221
LR  - 20221207
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 34
IP  - 6
DP  - 2013 Dec
TI  - Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric 
      cancer: a meta-analysis.
PG  - 3383-8
LID - 10.1007/s13277-013-0910-0 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an inflammatory cytokine which may play an 
      important role on the immune response may control the progression of gastric 
      cancer. Previous studies on the association between TNF-alpha 857C/T polymorphism and 
      gastric cancer risk reported conflicting results. We performed a meta-analysis to 
      comprehensively assess the association between TNF-alpha 857C/T polymorphism and 
      gastric cancer risk. Literature search was performed for all publications on the 
      association between TNF-alpha 857C/T polymorphism and gastric cancer risk through 
      March 6, 2013. The pooled odds ratios (ORs) with their 95% confidence interval 
      (95%CIs) were calculated to assess the association between TNF-alpha 857C/T 
      polymorphism and gastric cancer risk. Nine individual case-control studies with a 
      total of 5,054 subjects (1,835 cases and 3,219 controls) were finally included 
      into the meta-analysis. Meta-analysis of total nine studies showed that TNF-alpha 
      857C/T polymorphism was significantly associated with increased risk of gastric 
      cancer under four genetic models (for T vs. C: OR = 1.19, 95%CI 1.07-1.33, P = 
      0.002; for TT vs. CC: OR = 1.44, 95%CI 1.03-2.02, P = 0.032; for CT vs. CC: OR = 
      1.19, 95%CI 1.05-1.36, P = 0.008; and for TT/CT vs. CC: OR = 1.21, 95%CI 
      1.07-1.38, P = 0.003). Subgroup analysis by ethnicity further showed that there 
      was a significant association between TNF-alpha 857C/T polymorphism and increased 
      risk of gastric cancer in Asians but not in Caucasians. The meta-analysis 
      suggests that TNF-alpha 857C/T polymorphism is significantly associated with 
      increased risk of gastric cancer, especially in Asians.
FAU - Cen, Gang
AU  - Cen G
AD  - Department of Pediatric Surgery, Affiliated First People's Hospital, Shanghai 
      Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China.
FAU - Wu, Weidong
AU  - Wu W
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130703
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Stomach Neoplasms/ethnology/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/genetics
EDAT- 2013/07/04 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/07/04 06:00
PHST- 2013/05/10 00:00 [received]
PHST- 2013/05/31 00:00 [accepted]
PHST- 2013/07/04 06:00 [entrez]
PHST- 2013/07/04 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1007/s13277-013-0910-0 [doi]
PST - ppublish
SO  - Tumour Biol. 2013 Dec;34(6):3383-8. doi: 10.1007/s13277-013-0910-0. Epub 2013 Jul 
      3.