PMID- 23822491
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20130704
IS  - 1089-7682 (Electronic)
IS  - 1054-1500 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Jun
TI  - Experimental observation of transition from chaotic bursting to chaotic spiking 
      in a neural pacemaker.
PG  - 023126
LID - 10.1063/1.4810932 [doi]
AB  - The transition from chaotic bursting to chaotic spiking has been simulated and 
      analyzed in theoretical neuronal models. In the present study, we report 
      experimental observations in a neural pacemaker of a transition from chaotic 
      bursting to chaotic spiking within a bifurcation scenario from period-1 bursting 
      to period-1 spiking. This was induced by adjusting extracellular calcium or 
      potassium concentrations. The bifurcation scenario began from period-doubling 
      bifurcations or period-adding sequences of bursting pattern. This chaotic 
      bursting is characterized by alternations between multiple continuous spikes and 
      a long duration of quiescence, whereas chaotic spiking is comprised of fast, 
      continuous spikes without periods of quiescence. Chaotic bursting changed to 
      chaotic spiking as long interspike intervals (ISIs) of quiescence disappeared 
      within bursting patterns, drastically decreasing both ISIs and the magnitude of 
      the chaotic attractors. Deterministic structures of the chaotic bursting and 
      spiking patterns are also identified by a short-term prediction. The experimental 
      observations, which agree with published findings in theoretical neuronal models, 
      demonstrate the existence and reveal the dynamics of a neuronal transition from 
      chaotic bursting to chaotic spiking in the nervous system.
FAU - Gu, Huaguang
AU  - Gu H
AD  - School of Aerospace Engineering and Applied Mechanics, Tongji University, 
      Shanghai 200092, China. guhuaguang@tongji.edu.cn
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chaos
JT  - Chaos (Woodbury, N.Y.)
JID - 100971574
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Calcium/metabolism
MH  - Male
MH  - *Models, Neurological
MH  - *Nonlinear Dynamics
MH  - Potassium/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2013/07/05 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - 10.1063/1.4810932 [doi]
PST - ppublish
SO  - Chaos. 2013 Jun;23(2):023126. doi: 10.1063/1.4810932.