PMID- 23823139
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20240402
IS  - 1938-2731 (Electronic)
IS  - 1533-3175 (Print)
IS  - 1533-3175 (Linking)
VI  - 29
IP  - 5
DP  - 2014 Aug
TI  - Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and 
      Vascular Cognitive Impairment With No Dementia.
PG  - 474-81
LID - 10.1177/1533317513495106 [doi]
AB  - Amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment with 
      no dementia (VCIND) are highly predictive of Alzheimer's disease and vascular 
      dementia. In this study, a 2-dimensional magnetic resonance spectroscopy was 
      performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal 
      controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), 
      myoinositol (MI), and creatine (Cr) were measured, and their ratios were 
      calculated. The patients with aMCI displayed significantly lower NAA/MI 
      bilaterally in the posterior cingulate gyrus (PCG) and white matter of occipital 
      lobe (OLWM) than NC participants or patients with VCIND , whereas patients with 
      VCIND displayed markedly lower NAA/Cho bilaterally in the white matter of frontal 
      lobe (FLWM) and left OLWM, and right dorsal thalamus (DT) than patients with NC 
      or aMCI. Compared with the controls, patients with aMCI displayed lower NAA and 
      NAA/Cr in bilateral PCG, left precuneus, and DT, whereas patients with VCIND 
      displayed lower NAA/Cr in bilateral DT and FLWM. In addition, increased MI in 
      right PCG of patients with aMCI and increased Cho in left FLWM of patients with 
      VCIND were also observed. The results might help guide a clinical differentiation 
      between the 2 disorders.
CI  - (c) The Author(s) 2013.
FAU - Liu, Yan-Yan
AU  - Liu YY
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Yang, Zhong-Xian
AU  - Yang ZX
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Shen, Zhi-Wei
AU  - Shen ZW
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Xiao, Ye-Yu
AU  - Xiao YY
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Cheng, Xiao-Fang
AU  - Cheng XF
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Neurology, the Second Affiliated Hospital, Medical College of 
      Shantou University, Shantou, China.
FAU - Chen, Yao-Wen
AU  - Chen YW
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China.
FAU - Wu, Ren-Hua
AU  - Wu RH
AD  - Department of Medical Imaging Center, the Second Affiliated Hospital, Medical 
      College of Shantou University, Shantou, China Provincial Key Laboratory of 
      Medical Molecular Imaging, Guangdong, Shantou, China rhwu@stu.edu.cn.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130702
PL  - United States
TA  - Am J Alzheimers Dis Other Demen
JT  - American journal of Alzheimer's disease and other dementias
JID - 101082834
SB  - IM
MH  - Aged
MH  - Amnesia/*diagnostic imaging
MH  - Cerebrovascular Disorders/*diagnostic imaging
MH  - Cognition Disorders/*diagnostic imaging
MH  - Cognitive Dysfunction/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
PMC - PMC10852712
OTO - NOTNLM
OT  - MR spectroscopy
OT  - amnesic mild cognitive impairment
OT  - vascular cognitive impairment with no dementia
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2013/07/05 06:00
MHDA- 2016/12/15 06:00
PMCR- 2014/08/01
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 1533317513495106 [pii]
AID - 10.1177_1533317513495106 [pii]
AID - 10.1177/1533317513495106 [doi]
PST - ppublish
SO  - Am J Alzheimers Dis Other Demen. 2014 Aug;29(5):474-81. doi: 
      10.1177/1533317513495106. Epub 2013 Jul 2.