PMID- 23823484
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20131128
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 110
IP  - 12
DP  - 2013 Dec
TI  - Disruption of calmodulin-dependent protein kinase II alpha/brain-derived neurotrophic 
      factor (alpha-CaMKII/BDNF) signalling is associated with zinc deficiency-induced 
      impairments in cognitive and synaptic plasticity.
PG  - 2194-200
LID - 10.1017/S0007114513001657 [doi]
AB  - Maternal dietary Zn deficiency during fetal development induces substantial 
      cognitive dysfunctions in the resultant offspring. The mechanism underlying this 
      effect is unclear. The present study evaluated whether the impairments caused by 
      gestational and lactational Zn deficiency are mediated by the hippocampal 
      calmodulin-dependent protein kinase II alpha (alpha-CaMKII)/brain-derived neurotrophic 
      factor (BDNF) signalling pathway as well as whether they can be restored by 
      postnatal Zn supplementation. Rats were randomly divided into four groups on the 
      first day of pregnancy (n 12): control (CO) group; pair-fed (PF) group; 
      Zn-deprived (ZD) group; orally Zn-supplemented group. The spatial memory of the 
      offspring was tested at postnatal day 35 using the Morris water maze. Long-term 
      potentiation (LTP) in the rat hippocampal medial perforant path-dentate gyrus 
      pathway was evaluated simultaneously, and alpha-CaMKII and BDNF protein levels were 
      examined by Western blot analysis. The results demonstrated that the ZD group 
      exhibited a significantly longer latency period in the Morris water maze as well 
      as a significantly decreased LTP amplitude compared with the CO and PF groups. 
      alpha-CaMKII and BDNF protein expression in the hippocampus was significantly reduced 
      in the ZD group. Postnatal Zn supplementation restored the cognitive dysfunction 
      induced by gestational Zn deficiency but could not completely reverse the 
      decreased LTP and alpha-CaMKII/BDNF protein levels. Our findings suggest that the 
      alpha-CaMKII/BDNF signalling pathway may be involved in Zn deficiency-induced 
      cognitive and synaptic impairments.
FAU - Yu, XiaoDan
AU  - Yu X
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, XinHua Hospital, 
      Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 
      200092, People's Republic of China.
FAU - Ren, Tianhong
AU  - Ren T
FAU - Yu, XiaoGang
AU  - Yu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130703
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Trace Elements)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
MH  - Cognition Disorders/drug therapy/*etiology/metabolism/physiopathology
MH  - Deficiency Diseases/*complications/drug therapy/metabolism/physiopathology
MH  - *Dietary Supplements
MH  - Female
MH  - Hippocampus/drug effects/*physiopathology
MH  - Lactation
MH  - Male
MH  - Maze Learning
MH  - Memory Disorders/drug therapy/etiology/metabolism/physiopathology
MH  - Neuronal Plasticity/drug effects
MH  - Pregnancy
MH  - Prenatal Nutritional Physiological Phenomena
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Trace Elements/deficiency/therapeutic use
MH  - Zinc/*deficiency/therapeutic use
EDAT- 2013/07/05 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S0007114513001657 [pii]
AID - 10.1017/S0007114513001657 [doi]
PST - ppublish
SO  - Br J Nutr. 2013 Dec;110(12):2194-200. doi: 10.1017/S0007114513001657. Epub 2013 
      Jul 3.