PMID- 23824678
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 6
DP  - 2013
TI  - The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor 
      Gene in Coping Strategies Relevant to Depressive Symptoms.
PG  - e65547
LID - 10.1371/journal.pone.0065547 [doi]
LID - e65547
AB  - Disturbances of brain derived neurotrophic factor (BDNF) signalling have been 
      implicated in the evolution of depression, which likely arises, in part, as a 
      result of diminished synaptic plasticity. Predictably, given stressor involvement 
      in depression, BDNF is affected by recent stressors as well as stressors such as 
      neglect experienced in early life. The effects of early life maltreatment in 
      altering BDNF signalling may be particularly apparent among those individuals 
      with specific BDNF polymorphisms. We examined whether polymorphisms of the 
      Val66Met genotype might be influential in moderating how early-life events play 
      out with respect to later coping styles, cognitive flexibility and depressive 
      features. Among male and female undergraduate students (N = 124), childhood 
      neglect was highly related to subsequent depressive symptoms. This outcome was 
      moderated by the BDNF polymorphism in the sense that depressive symptoms appeared 
      higher in Met carriers who reported low levels of neglect than in those with the 
      Val/Val allele. However, under conditions of high neglect depressive symptoms 
      only increased in the Val/Val individuals. In effect, the Met polymorphism was 
      associated with depressive features, but did not interact with early life neglect 
      in predicting later depressive features. It was further observed that among the 
      Val/Val individuals, the relationship between neglect and depression was mediated 
      by emotion-focused styles and diminished perceived control, whereas this 
      mediation was not apparent in Met carriers. In contrast to the more typical view 
      regarding this polymorphism, the data are consistent with the perspective that in 
      the presence of synaptic plasticity presumably associated with the Val/Val 
      genotype, neglect allows for the emergence of specific appraisal and coping 
      styles, which are tied to depression. In the case of the reduced degree of 
      neuroplasticity expected in the Met carriers, early life adverse experiences are 
      not tied to coping styles, and hence less likely to be translated into depressive 
      states.
FAU - Caldwell, Warren
AU  - Caldwell W
AD  - Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
FAU - McInnis, Opal A
AU  - McInnis OA
FAU - McQuaid, Robyn J
AU  - McQuaid RJ
FAU - Liu, Gele
AU  - Liu G
FAU - Stead, John D
AU  - Stead JD
FAU - Anisman, Hymie
AU  - Anisman H
FAU - Hayley, Shawn
AU  - Hayley S
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
DEP - 20130618
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adaptation, Psychological/*physiology
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/genetics/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - *Polymorphism, Genetic
MH  - Valine/*genetics
MH  - Young Adult
PMC - PMC3688808
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/07/05 06:00
MHDA- 2013/07/05 06:01
PMCR- 2013/06/18
CRDT- 2013/07/05 06:00
PHST- 2013/02/07 00:00 [received]
PHST- 2013/04/25 00:00 [accepted]
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2013/07/05 06:01 [medline]
PHST- 2013/06/18 00:00 [pmc-release]
AID - PONE-D-13-06150 [pii]
AID - 10.1371/journal.pone.0065547 [doi]
PST - epublish
SO  - PLoS One. 2013 Jun 18;8(6):e65547. doi: 10.1371/journal.pone.0065547. Print 2013.