PMID- 23825628
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 6
DP  - 2013
TI  - Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid 
      structure simulation.
PG  - e67097
LID - 10.1371/journal.pone.0067097 [doi]
LID - e67097
AB  - Dilated cardiomyopathy (DCM) is the most common myocardial disease. It not only 
      leads to systolic dysfunction but also diastolic deficiency. We sought to 
      investigate the effect of idiopathic and ischemic DCM on the intraventricular 
      fluid dynamics and myocardial wall mechanics using a 2D axisymmetrical fluid 
      structure interaction model. In addition, we also studied the individual effect 
      of parameters related to DCM, i.e. peak E-wave velocity, end systolic volume, 
      wall compliance and sphericity index on several important fluid dynamics and 
      myocardial wall mechanics variables during ventricular filling. Intraventricular 
      fluid dynamics and myocardial wall deformation are significantly impaired under 
      DCM conditions, being demonstrated by low vortex intensity, low flow propagation 
      velocity, low intraventricular pressure difference (IVPD) and strain rates, and 
      high-end diastolic pressure and wall stress. Our sensitivity analysis results 
      showed that flow propagation velocity substantially decreases with an increase in 
      wall stiffness, and is relatively independent of preload at low-peak E-wave 
      velocity. Early IVPD is mainly affected by the rate of change of the early 
      filling velocity and end systolic volume which changes the ventriculo:annular 
      ratio. Regional strain rate, on the other hand, is significantly correlated with 
      regional stiffness, and therefore forms a useful indicator for myocardial 
      regional ischemia. The sensitivity analysis results enhance our understanding of 
      the mechanisms leading to clinically observable changes in patients with DCM.
FAU - Chan, Bee Ting
AU  - Chan BT
AD  - Department of Biomedical Engineering, Faculty of Engineering, University of 
      Malaya, Kuala Lumpur, Malaysia. beetn_chan@yahoo.com
FAU - Abu Osman, Noor Azuan
AU  - Abu Osman NA
FAU - Lim, Einly
AU  - Lim E
FAU - Chee, Kok Han
AU  - Chee KH
FAU - Abdul Aziz, Yang Faridah
AU  - Abdul Aziz YF
FAU - Abed, Amr Al
AU  - Abed AA
FAU - Lovell, Nigel H
AU  - Lovell NH
FAU - Dokos, Socrates
AU  - Dokos S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130625
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Cardiomyopathy, Dilated/complications/*pathology/*physiopathology
MH  - Heart Ventricles/*pathology/*physiopathology
MH  - Humans
MH  - *Hydrodynamics
MH  - *Models, Cardiovascular
MH  - Myocardial Infarction/complications
MH  - Organ Size
MH  - Stress, Mechanical
MH  - Stroke Volume
PMC - PMC3692440
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/07/05 06:00
MHDA- 2014/02/08 06:00
PMCR- 2013/06/25
CRDT- 2013/07/05 06:00
PHST- 2013/02/13 00:00 [received]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
PHST- 2013/06/25 00:00 [pmc-release]
AID - PONE-D-13-06321 [pii]
AID - 10.1371/journal.pone.0067097 [doi]
PST - epublish
SO  - PLoS One. 2013 Jun 25;8(6):e67097. doi: 10.1371/journal.pone.0067097. Print 2013.