PMID- 23825860
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130705
LR  - 20220310
IS  - 0019-5545 (Print)
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 55
IP  - 2
DP  - 2013 Apr
TI  - Ventricular premature contractions associated with iloperidone.
PG  - 195-6
LID - 10.4103/0019-5545.111464 [doi]
AB  - Typical and atypical antipsychotic drugs are known to block potassium 
      repolarization channels, prolong the QTc interval, and thereby predispose to 
      ventricular tachyarrhythmias. We report a young male schizophrenic patient who 
      experienced clinically significant and symptomatically distressing ventricular 
      premature contractions (VPCs) in close temporal relation with iloperidone (8-16 
      mg/day) treatment; there had been no VPCs with prior exposure to risperidone, 
      trihexyphenidyl, and olanzapine, nor with subsequent exposure to asenapine. We 
      hypothesize that the VPCs may have been triggered by an alpha 2c receptor 
      blockade-mediated cardiostimulatory action associated with iloperidone.
FAU - Achalia, Rashmin
AU  - Achalia R
AD  - Department of Psychiatry, Government Medical College, Aurangabad, Maharashtra, 
      India.
FAU - Andrade, Chittaranjan
AU  - Andrade C
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3696249
OTO - NOTNLM
OT  - Adverse effects
OT  - antipsychotic drugs
OT  - cardiac arrhythmia
OT  - heart
OT  - iloperidone
OT  - ventricular premature contractions
COIS- Conflict of Interest: None declared
EDAT- 2013/07/05 06:00
MHDA- 2013/07/05 06:01
PMCR- 2013/04/01
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2013/07/05 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - IJPsy-55-195 [pii]
AID - 10.4103/0019-5545.111464 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2013 Apr;55(2):195-6. doi: 10.4103/0019-5545.111464.