PMID- 23825980 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130705 LR - 20211021 IS - 1726-913X (Print) IS - 1726-9148 (Electronic) IS - 1726-913X (Linking) VI - 11 IP - 2 DP - 2013 Spring TI - Liver and plasma nesfatin-1 responses to 6 weeks of treadmill running with or without zizyphus jujuba liquid extract in female rat. PG - 95-101 LID - 10.5812/ijem.8438 [doi] AB - BACKGROUND: Nesfatin-1 is a protein derived from a precursor molecule of the nucleobindin-2 gene, and acts as an anorexigenic peptide on food intake behavior, and its level isinfluenced by nutritional status, food composition [fat and carbohydrate (CHO)], and physical exercise. OBJECTIVES: The aim of this study was to investigate the effects of 6 weeks of treadmill running (at high intensity) program with and without zizyphus jujuba (high carbohydrate content) crud extraction on liver nesfatin-1, ATP, glycogen, and its plasma concentrations in female rats. MATERIALS AND METHODS: Twenty-eight Wistar female rats (6-8 weeks old100-120 g of weight) were randomly assigned to saline-control (SC), saline-training (ST), zizyphus jujuba-control (ZJC), and zizyphus jujuba-training (ZJT) groups. Rats ran on a motor-driven treadmill at 35 m/min, 60 min/day, 5 days/week for 6 weeks. Animals received ZJ extraction and saline at the dose of 1.25 mL/100g of body weight. Seventy-two hours after the last training session rats were killed, a portion of liver excited, and plasma was collected for nesfatin-1, ATP, and glycogen measurements. A one-way ANOVA method, and Pearson correlation were employed. P < 0.05 was considered as significant. RESULTS: A higher and significant liver nesfatin-1 level was found in ZJ groups (p < 0.005), but plasma nesfatin-1 responded differently. Changes in liver nesfatin-1 were accompanied with an increase in liver glycogen,but not ATP contents. CONCLUSIONS: The Findings indicate that higher liver nesfatin-1 and glycogen content by ZJ extraction might be due to the ZJ high CHO content, and it could be consideredas an anti-appetite herb. FAU - Ghanbari Niaki, Abbass AU - Ghanbari Niaki A AD - Exercise Biochemistry Division, Department of Physical Education and Sport Sciences, University of Mazandarn, Baboulsar, IR Iran. FAU - Mohammadi Joojadeh, Fatemeh AU - Mohammadi Joojadeh F FAU - Zare Kookandeh, Navabeh AU - Zare Kookandeh N FAU - Najafi, Safar AU - Najafi S FAU - Chaichi, Mohammad Javad AU - Chaichi MJ FAU - Rodbari, Fatemeh AU - Rodbari F FAU - Bayat, Hasan AU - Bayat H LA - eng PT - Journal Article DEP - 20130401 PL - Netherlands TA - Int J Endocrinol Metab JT - International journal of endocrinology and metabolism JID - 101235597 PMC - PMC3693664 OTO - NOTNLM OT - Endurance Training OT - Nesfatin-1 OT - Zizyphus Jujuba EDAT- 2013/07/05 06:00 MHDA- 2013/07/05 06:01 PMCR- 2013/03/01 CRDT- 2013/07/05 06:00 PHST- 2012/10/12 00:00 [received] PHST- 2013/01/20 00:00 [revised] PHST- 2013/02/13 00:00 [accepted] PHST- 2013/07/05 06:00 [entrez] PHST- 2013/07/05 06:00 [pubmed] PHST- 2013/07/05 06:01 [medline] PHST- 2013/03/01 00:00 [pmc-release] AID - 10.5812/ijem.8438 [doi] PST - ppublish SO - Int J Endocrinol Metab. 2013 Spring;11(2):95-101. doi: 10.5812/ijem.8438. Epub 2013 Apr 1.