PMID- 23827062
OWN - NLM
STAT- MEDLINE
DCOM- 20140428
LR  - 20130705
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 35
IP  - 3
DP  - 2013 Jun
TI  - [Morphological study on early development of brain derived neurophic 
      factor-positive neurons in the frontal lobe of human fetus].
PG  - 260-4
LID - 10.3881/j.issn.1000-503X.2013.03.004 [doi]
AB  - OBJECTIVE: To investigate the growth and development of brain derived neurophic 
      factor(BDNF)-positive neurons in the frontal lobe of human fetus. METHODS: The 
      expression of the BDNF-positive neurons in the frontal lobe of human fetus in the 
      2(nd),3(rd),and 4(th) month of gestation were observed with the 
      streptavidin-biotin-complex/immunoperoxidase(SABC)method. RESULTS: By the second 
      month of gestation,BDNF-positive neurons were seen in the subventricular layer of 
      the frontal lobe of cerebellum.By the third month of gestation,BDNF-positive 
      neurons in the central layer were in various shapes,with big nucleus,less 
      cytoplasm,and small processes.By the fourth month of gestation,BDNF-positive 
      neurons in the central layer grew larger in size,cytoplasm increased,the 
      BDNF-positive expression was enhanced with deeper dyeing,and the nerve fibers and 
      particles were distributed between neurons;also,the BDNF-positive neurons were 
      seen in the marginal layer of the frontal lobe of cerebrum. CONCLUSION: 
      BDNF-positive neurons may participate in the early development of the frontal 
      lobe of cerebrum of human fetus.
FAU - Zheng, Lan-rong
AU  - Zheng LR
AD  - Department of Pathology,Wannan Medical College,Wuhu, Anhui, China.
FAU - Zhu, Xiao-qun
AU  - Zhu XQ
FAU - Huang, Xiao-mei
AU  - Huang XM
FAU - Gu, Qian
AU  - Gu Q
FAU - Xie, Dong-hui
AU  - Xie DH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Fetus/*metabolism
MH  - Frontal Lobe/*embryology
MH  - Humans
MH  - Neurons/*cytology/metabolism
EDAT- 2013/07/06 06:00
MHDA- 2014/04/29 06:00
CRDT- 2013/07/06 06:00
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2014/04/29 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.2013.03.004 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Jun;35(3):260-4. doi: 
      10.3881/j.issn.1000-503X.2013.03.004.