PMID- 23827216
OWN - NLM
STAT- MEDLINE
DCOM- 20140411
LR  - 20221207
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 550
DP  - 2013 Aug 29
TI  - Neuroprotective and procognitive effects of sertraline: in vitro and in vivo 
      studies.
PG  - 93-7
LID - S0304-3940(13)00580-6 [pii]
LID - 10.1016/j.neulet.2013.06.033 [doi]
AB  - Selective serotonin reuptake inhibitors (SSRIs) stimulate synaptic plasticity and 
      neurogenesis, most likely via the MAP-kinase signal transduction pathway (by 
      phosphorilation of ERK) and by stimulating neurotrophic factors such as brain 
      derived neurotrophic factor (BDNF) and the neuroprotective protein (Bcl-2). Using 
      human neuroblastoma cells (SHSY5Y), we found that sertraline and its derivative, 
      desmethylsertraline, at low concentrations (1-10 muM), induced potent neurotrophic 
      activity. Subsequently, we have treated for 21 days young and aged mice with 
      sertraline. Sertraline in certain doses improved significantly spatial memory 
      learning, in both young and old mice. Sertraline treatment resulted in 
      up-regulation of brain BDNF, phospho-ERK and Bcl-2 that may be involved in the 
      pro-cognitive effect of sertraline.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Taler, Michal
AU  - Taler M
AD  - Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and 
      Sackler Faculty of Medicine, Tel Aviv University, Israel. michalt@post.tau.ac.il
FAU - Miron, Oded
AU  - Miron O
FAU - Gil-Ad, Irit
AU  - Gil-Ad I
FAU - Weizman, Abraham
AU  - Weizman A
LA  - eng
PT  - Journal Article
DEP - 20130701
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nootropic Agents)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Line, Tumor
MH  - Hippocampus/*drug effects/metabolism
MH  - Humans
MH  - Maze Learning/*drug effects
MH  - Mice
MH  - Neurons/*drug effects/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Nootropic Agents/*pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Sertraline/*pharmacology
MH  - Up-Regulation/drug effects
OTO - NOTNLM
OT  - BDNF
OT  - Cognition
OT  - Neuroprotection
OT  - Selective serotonin reuptake inhibitors
OT  - Sertraline
EDAT- 2013/07/06 06:00
MHDA- 2014/04/12 06:00
CRDT- 2013/07/06 06:00
PHST- 2013/03/21 00:00 [received]
PHST- 2013/06/06 00:00 [revised]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2014/04/12 06:00 [medline]
AID - S0304-3940(13)00580-6 [pii]
AID - 10.1016/j.neulet.2013.06.033 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Aug 29;550:93-7. doi: 10.1016/j.neulet.2013.06.033. Epub 2013 
      Jul 1.