PMID- 23827293
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20211021
IS  - 1478-7083 (Electronic)
IS  - 0035-8843 (Print)
IS  - 0035-8843 (Linking)
VI  - 95
IP  - 3
DP  - 2013 Apr
TI  - Assessing the effectiveness of retrograde autologous priming of the 
      cardiopulmonary bypass machine in isolated coronary artery bypass grafts.
PG  - 207-10
LID - 10.1308/003588413X13511609956859 [doi]
AB  - INTRODUCTION: Currently, around 35-80% of patients undergoing cardiac surgery in 
      the UK receive a blood transfusion. Retrograde autologous priming (RAP) of the 
      cardiopulmonary bypass circuit has been suggested as a possible strategy to 
      reduce blood transfusion during cardiac surgery. METHODS: Data from 101 
      consecutive patients undergoing isolated coronary artery bypass grafts (where RAP 
      was used) were collected prospectively and compared with 92 historic patients 
      prior to RAP use in our centre. RESULTS: Baseline characteristics (ie age, 
      preoperative haemoglobin [Hb] etc) were not significantly different between the 
      RAP and non-RAP groups. The mean pump priming volume of 1,013ml in the RAP group 
      was significantly lower (p<0.001) than that of 2,450ml in the non-RAP group. The 
      mean Hb level at initiation of bypass of 9.1g/dl in patients having RAP was 
      significantly higher (p<0.001) than that of 7.7g/dl in those who did not have 
      RAP. There was no significant difference between the RAP and non-RAP groups in 
      transfusion of red cells, platelets and fresh frozen plasma, 30-day mortality, 
      re-exploration rate and predischarge Hb level. The median durations of cardiac 
      intensive care unit stay and in-hospital stay of 1 day (inter-quartile range 
      [IQR]: 1-2 days) and 5 days (IQR: 4-6 days) in the RAP group were significantly 
      shorter than those of the non-RAP group (2 days [IQR: 1-3 days] and 6 days [IQR: 
      5-9 days]). CONCLUSIONS: In the population group studied, RAP did not influence 
      blood transfusion rates but was associated with a reduction in duration of 
      hospital stay.
FAU - Kearsey, C
AU  - Kearsey C
AD  - Royal Wolverhampton NHS Trust, UK. cck1@doctors.org.uk
FAU - Thekkudan, J
AU  - Thekkudan J
FAU - Robbins, S
AU  - Robbins S
FAU - Ng, A
AU  - Ng A
FAU - Lakshmanan, S
AU  - Lakshmanan S
FAU - Luckraz, H
AU  - Luckraz H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann R Coll Surg Engl
JT  - Annals of the Royal College of Surgeons of England
JID - 7506860
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Aged
MH  - Blood Transfusion, Autologous/methods
MH  - Coronary Artery Bypass/instrumentation/*methods
MH  - Female
MH  - Hemodilution/methods
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Male
MH  - Prospective Studies
PMC - PMC4165246
EDAT- 2013/07/06 06:00
MHDA- 2013/09/14 06:00
PMCR- 2013/04/01
CRDT- 2013/07/06 06:00
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - 956859 [pii]
AID - 10.1308/003588413X13511609956859 [doi]
PST - ppublish
SO  - Ann R Coll Surg Engl. 2013 Apr;95(3):207-10. doi: 
      10.1308/003588413X13511609956859.