PMID- 23827956
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220408
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 13
IP  - 8
DP  - 2013 Aug
TI  - The role of dendritic cells in autoimmunity.
PG  - 566-77
LID - 10.1038/nri3477 [doi]
AB  - Dendritic cells (DCs) initiate and shape both the innate and adaptive immune 
      responses. Accordingly, recent evidence from clinical studies and experimental 
      models implicates DCs in the pathogenesis of most autoimmune diseases. However, 
      fundamental questions remain unanswered concerning the actual roles of DCs in 
      autoimmunity, both in general and, in particular, in specific diseases. In this 
      Review, we discuss the proposed roles of DCs in immunological tolerance, the 
      effect of the gain or loss of DCs on autoimmunity and DC-intrinsic molecular 
      regulators that help to prevent the development of autoimmunity. We also review 
      the emerging roles of DCs in several autoimmune diseases, including autoimmune 
      myocarditis, multiple sclerosis, psoriasis, type 1 diabetes and systemic lupus 
      erythematosus.
FAU - Ganguly, Dipyaman
AU  - Ganguly D
AD  - Department of Microbiology and Immunology, Columbia University Medical Center, 
      New York, New York 10032, USA.
FAU - Haak, Stefan
AU  - Haak S
FAU - Sisirak, Vanja
AU  - Sisirak V
FAU - Reizis, Boris
AU  - Reizis B
LA  - eng
GR  - R01 AI072571/AI/NIAID NIH HHS/United States
GR  - AI072571/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130705
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
SB  - IM
MH  - *Adaptive Immunity
MH  - Animals
MH  - *Autoimmunity
MH  - Dendritic Cells/*immunology
MH  - Diabetes Mellitus, Type 1/immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Mice
MH  - Multiple Sclerosis/immunology
MH  - Myocarditis/immunology
MH  - Psoriasis/immunology
MH  - Rats
MH  - *Self Tolerance
PMC - PMC4160805
MID - NIHMS622733
EDAT- 2013/07/06 06:00
MHDA- 2013/10/01 06:00
PMCR- 2014/09/11
CRDT- 2013/07/06 06:00
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
PHST- 2014/09/11 00:00 [pmc-release]
AID - nri3477 [pii]
AID - 10.1038/nri3477 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2013 Aug;13(8):566-77. doi: 10.1038/nri3477. Epub 2013 Jul 5.