PMID- 23828292
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20220330
IS  - 0022-4707 (Print)
IS  - 0022-4707 (Linking)
VI  - 53
IP  - 4
DP  - 2013 Aug
TI  - Effect of six weeks of endurance exercise and following detraining on serum brain 
      derived neurotrophic factor and memory performance in middle aged males with 
      metabolic syndrome.
PG  - 437-43
AB  - AIM: Brain derived neurotrophic factor (BDNF) and physical inactivity contribute 
      to the development of metabolic syndrome (MetS). Aerobic training has been 
      reported to improve MetS, however less attention has been directed toward the 
      role of training and detraining on cognitive function in MetS. METHODS: Twenty 
      one healthy middle-aged males and 21 with MetS were distributed into four groups: 
      MetS exercise (ME), MetS control (MC), Healthy exercise (HE) and healthy control 
      (HC). Both ME and HE, followed a 6-week aerobic training program (3 
      sessions/week). Digit Span memory test and blood sampling were conducted pre 
      training, post training and also following a six weeks detraining. Data were 
      analyzed using spearman, pearson and repeated measure ANOVA tests. RESULTS: 
      Baseline serum BDNF level was positively correlated with waist circumference 
      (r=0.383, P=0.012) and showed significant elevation in MetS compared with healthy 
      subjects (1101.66+/-61.34 vs. 903.72+/-46.57 pg/mL, P=0.014). After aerobic exercise 
      BDNF level significantly increased in HE, but decreased in ME group (P=0.001). 
      Both short and mid term memory significantly increased (P<0.05) only in HE group. 
      CONCLUSION: Exercise induced cognitive improvement might be mediated via 
      BDNF-linked mechanisms in healthy people. However, the health status of 
      individuals should be considered.
FAU - Babaei, P
AU  - Babaei P
AD  - Cellelar and Molecular Research Center, Guilan University of Medical Sciences 
      Rasht, Iran - damirchi@guilan.ac.ir.
FAU - Azali Alamdari, K
AU  - Azali Alamdari K
FAU - Soltani Tehrani, B
AU  - Soltani Tehrani B
FAU - Damirchi, A
AU  - Damirchi A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Attention/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/*physiology
MH  - Exercise/*psychology
MH  - Exercise Therapy/*methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/physiopathology/*rehabilitation
MH  - Middle Aged
MH  - Resistance Training/*methods
MH  - Time Factors
MH  - Treatment Outcome
MH  - Waist Circumference
EDAT- 2013/07/06 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/07/06 06:00
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - R40Y2013N04A0437 [pii]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2013 Aug;53(4):437-43.