PMID- 23828555
OWN - NLM
STAT- MEDLINE
DCOM- 20140602
LR  - 20211021
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Print)
IS  - 0946-2716 (Linking)
VI  - 91
IP  - 11
DP  - 2013 Nov
TI  - The skinny on brain-derived neurotrophic factor: evidence from animal models to 
      GWAS.
PG  - 1241-7
LID - 10.1007/s00109-013-1071-8 [doi]
AB  - Obesity and its sequelae constitute a major international healthcare problem. The 
      obesity epidemic is due in part to higher calorie diets and reduced exercise over 
      the past 30 years; however, increasing evidence has established genetic 
      regulation of body weight as a major contributor to obesity. Brain-derived 
      neurotrophic factor (BDNF) regulates development and plasticity of the central 
      nervous system, and recent work has established a clear role for signaling 
      through BDNF and its receptor TrkB in the control of body weight. Here we review 
      research findings from animal models and human populations indicating that BDNF 
      is a negative regulator of appetitive behavior and body weight.
FAU - Waterhouse, Emily G
AU  - Waterhouse EG
AD  - Department of Pharmacology and Physiology, Georgetown University Medical Center, 
      Washington, DC, 20057, USA.
FAU - Xu, Baoji
AU  - Xu B
LA  - eng
GR  - F30 DK084717/DK/NIDDK NIH HHS/United States
GR  - R01 DK089237/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130705
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Disease Models, Animal
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Obesity/*genetics/*metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction
PMC - PMC3815745
MID - NIHMS502409
EDAT- 2013/07/06 06:00
MHDA- 2014/06/03 06:00
PMCR- 2014/11/01
CRDT- 2013/07/06 06:00
PHST- 2013/01/08 00:00 [received]
PHST- 2013/06/25 00:00 [accepted]
PHST- 2013/06/02 00:00 [revised]
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2014/06/03 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - 10.1007/s00109-013-1071-8 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2013 Nov;91(11):1241-7. doi: 10.1007/s00109-013-1071-8. Epub 
      2013 Jul 5.