PMID- 23828864
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20131204
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 9
IP  - 23
DP  - 2013 Dec 9
TI  - Reduced graphene oxide-functionalized high electron mobility transistors for 
      novel recognition pattern label-free DNA sensors.
PG  - 4045-50
LID - 10.1002/smll.201300793 [doi]
AB  - We designed and constructed reduced graphene oxide (rGO) functionalized high 
      electron mobility transistor (HEMT) for rapid and ultra-sensitive detection of 
      label-free DNA in real time. The micrometer sized rGO sheets with structural 
      defects helped absorb DNA molecules providing a facile and robust approach to 
      functionalization. DNA was immobilized onto the surface of HEMT gate through rGO 
      functionalization, and changed the conductivity of HEMT. The real time monitor 
      and detection of DNA hybridization by rGO functionalized HEMT presented 
      interesting current responses: a "two steps" signal enhancement in the presence 
      of target DNA; and a "one step" signaling with random DNA. These two different 
      recognition patterns made the HEMT capable of specifically detecting target DNA 
      sequence. The working principle of the rGO functionalized HEMT can be 
      demonstrated as the variation of the ambience charge distribution. Furthermore, 
      the as constructed DNA sensors showed excellent sensitivity of detect limit at 
      0.07 fM with linear detect range from 0.1 fM to 0.1 pM. The results indicated 
      that the HEMT functionalized with rGO paves a new avenue to design novel 
      electronic devices for high sensitive and specific genetic material assays in 
      biomedical applications.
CI  - Copyright (c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Zhang, Xiaohui
AU  - Zhang X
AD  - State Key Laboratory for Advanced Metals and Materials, School of Materials 
      Science and Engineering, University of Science and Technology Beijing, Beijing 
      100083, PR China; Pacific Northwest National Laboratory, Richland, WA 99352, USA.
FAU - Zhang, Yue
AU  - Zhang Y
FAU - Liao, Qingliang
AU  - Liao Q
FAU - Song, Yu
AU  - Song Y
FAU - Ma, Siwei
AU  - Ma S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130705
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 7782-42-5 (Graphite)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Biosensing Techniques/*methods
MH  - DNA/*chemistry
MH  - Graphite/*chemistry
MH  - *Transistors, Electronic
OTO - NOTNLM
OT  - DNA
OT  - label-free sensors
OT  - reduced graphene oxide
OT  - transistors
EDAT- 2013/07/06 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/07/06 06:00
PHST- 2013/03/13 00:00 [received]
PHST- 2013/04/07 00:00 [revised]
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - 10.1002/smll.201300793 [doi]
PST - ppublish
SO  - Small. 2013 Dec 9;9(23):4045-50. doi: 10.1002/smll.201300793. Epub 2013 Jul 5.