PMID- 23828958
OWN - NLM
STAT- MEDLINE
DCOM- 20130715
LR  - 20190907
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 169
IP  - 1
DP  - 2013 Jul
TI  - Shortness: an unknown phenotype of multiple endocrine neoplasia type 1.
PG  - 133-7
AB  - OBJECTIVE: An observation of shortness among the female participants of a regular 
      screening program in multiple endocrine neoplasia type 1 (MEN1) patients has 
      raised the question as to whether shortness represents a phenotype characteristic 
      of the disease. METHODS: The body height (cm) of genetically confirmed MEN1 
      patients at the time of diagnosis was compared with the body height of their 
      unaffected relatives (parents, siblings, and children), the midparental body 
      height, and the body height of the age-matched German population. Univariate 
      analysis of the clinical variables was performed using the t-test, Mann-Whitney U 
      test, and ANOVA as appropriate, and multivariate analysis was performed as a 
      logistic regression analysis. P values <0.05 were considered statistically 
      significant. RESULTS: The mean body height of 22 female MEN1 patients (mean age 
      33.5 years) was 161 +/- 5 cm and thus significantly lesser than the body heights 
      of their unaffected female relatives (mean 165.5 +/- 7.3 cm, P=0.027) and the 
      age-matched German female population (mean 167 cm, P=0.0001) and mid-parental 
      height (177.5 cm, P<0.0001). The mean body height of 24 male MEN1 patients (mean 
      age 34.8 years) was also lesser (177 +/- 6.5 cm) than the average body height of 
      German males in this age group (180 cm, P=0.031) and tended to be lesser than 
      that of their unaffected male relatives (178.5 +/- 5.8 cm, P=0.0915) and the 
      mid-parental body height (177.5 cm, P=0.124). CONCLUSIONS: Small body height is a 
      yet unrecognized phenotype characteristic of MEN1 patients, especially in women. 
      The mechanisms behind this phenotypical characteristic warrant further 
      investigation.
FAU - Lopez, Caroline L
AU  - Lopez CL
AD  - Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany. 
      lopez@med.uni-marburg.de
FAU - Langer, Peter
AU  - Langer P
FAU - Waldmann, Jens
AU  - Waldmann J
FAU - Fendrich, Volker
AU  - Fendrich V
FAU - Sitter, Helmut
AU  - Sitter H
FAU - Nies, Christoph
AU  - Nies C
FAU - Bartsch, Detlef K
AU  - Bartsch DK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Body Height/*genetics
MH  - Female
MH  - *Germ-Line Mutation
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/genetics
MH  - Parents
MH  - Phenotype
MH  - Proto-Oncogene Proteins/*genetics
EDAT- 2013/07/06 06:00
MHDA- 2013/07/17 06:00
CRDT- 2013/07/06 06:00
PHST- 2013/07/06 06:00 [entrez]
PHST- 2013/07/06 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - 10.1530/eje-13-0126 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2013 Jul;169(1):133-7. doi: 10.1530/eje-13-0126.