PMID- 23829668
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 13
DP  - 2013 Jul 6
TI  - The effect of Chinese Jinzhida recipe on the hippocampus in a rat model of 
      diabetes-associated cognitive decline.
PG  - 161
LID - 10.1186/1472-6882-13-161 [doi]
AB  - BACKGROUND: To investigate the effects of treatment with Multi component Chinese 
      Medicine Jinzhida (JZD) on behavioral deficits in diabetes-associated cognitive 
      decline (DACD) rats and verify our hypothesis that JZD treatment improves 
      cognitive function by suppressing the endoplasmic reticulum stress (ERS) and 
      improving insulin signaling transduction in the rats' hippocampus. METHODS: A rat 
      model of type 2 diabetes mellitus (T2DM) was established using high fat diet and 
      streptozotocin (30 mg/kg, ip). Insulin sensitivity was evaluated by the oral 
      glucose tolerance test and the insulin tolerance test. After 7 weeks, the T2DM 
      rats were treated with JZD. The step-down test and Morris water maze were used to 
      evaluate behavior in T2DM rats after 5 weeks of treatment with JZD. Levels of 
      phosphorylated proteins involved in the ERS and in insulin signaling transduction 
      pathways were assessed by Western blot for T2DM rats' hippocampus. RESULTS: 
      Compared to healthy control rats, T2DM rats initially showed insulin resistance 
      and had declines in acquisition and retrieval processes in the step-down test and 
      in spatial memory in the Morris water maze after 12 weeks. Performance on both 
      the step-down test and Morris water maze tasks improved after JZD treatment. In 
      T2DM rats, the ERS was activated, and then inhibited the insulin signal 
      transduction pathways through the Jun NH2-terminal kinases (JNK) mediated. JZD 
      treatment suppressed the ERS, increased insulin signal transduction, and improved 
      insulin resistance in the rats' hippocampus. CONCLUSIONS: Treatment with JZD 
      improved cognitive function in the T2DM rat model. The possible mechanism for 
      DACD was related with ERS inducing the insulin signal transduction dysfunction in 
      T2DM rats' hippocampus. The JZD could reduce ERS and improve insulin signal 
      transduction and insulin resistance in T2DM rats' hippocampus and as a result 
      improved the cognitive function.
FAU - Chang, Xiao-Hui
AU  - Chang XH
FAU - Liang, Li-Na
AU  - Liang LN
FAU - Zhan, Li-Bin
AU  - Zhan LB
FAU - Lu, Xiao-Guang
AU  - Lu XG
FAU - Shi, Xiang
AU  - Shi X
FAU - Qi, Xin
AU  - Qi X
FAU - Feng, Zhao-Lan
AU  - Feng ZL
FAU - Wu, Mei-Juan
AU  - Wu MJ
FAU - Sui, Hua
AU  - Sui H
FAU - Zheng, Lu-Ping
AU  - Zheng LP
FAU - Zhang, Fu-Liang
AU  - Zhang FL
FAU - Sun, Jie
AU  - Sun J
FAU - Bai, Chang-Chuan
AU  - Bai CC
FAU - Li, Nan
AU  - Li N
FAU - Han, Guo-Zhu
AU  - Han GZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130706
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Insulin)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Camellia sinensis
MH  - Cognition/*drug effects
MH  - Cognition Disorders/*drug therapy/etiology/metabolism
MH  - Diabetes Mellitus, Experimental/complications/drug therapy/metabolism/psychology
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/metabolism/*psychology
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Glucose Tolerance Test
MH  - Hippocampus/*drug effects/metabolism
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Male
MH  - Panax
MH  - Phosphorylation
MH  - *Phytotherapy
MH  - Polygala
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
PMC - PMC3735391
EDAT- 2013/07/09 06:00
MHDA- 2014/10/07 06:00
PMCR- 2013/07/06
CRDT- 2013/07/09 06:00
PHST- 2013/01/16 00:00 [received]
PHST- 2013/07/04 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
PHST- 2013/07/06 00:00 [pmc-release]
AID - 1472-6882-13-161 [pii]
AID - 10.1186/1472-6882-13-161 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2013 Jul 6;13:161. doi: 10.1186/1472-6882-13-161.