PMID- 23829868 OWN - NLM STAT- MEDLINE DCOM- 20140213 LR - 20211021 IS - 1423-0127 (Electronic) IS - 1021-7770 (Print) IS - 1021-7770 (Linking) VI - 20 IP - 1 DP - 2013 Jul 5 TI - Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies. PG - 47 LID - 10.1186/1423-0127-20-47 [doi] AB - The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair the proper control of vascular responses by the NVU. Magnetic resonance imaging, which is the most powerful tool available to investigate neurovascular structures or functions, will be discussed in the present article in relation to its applications and discoveries. Because aberrant angiogenesis and vascular remodeling have been increasingly reported as being implicated in brain pathogenesis, this review article will refer to this hallmark event when suitable. FAU - Chen, Chiao-Chi V AU - Chen CC AD - Institute of Biomedical Sciences, Academic Sinica, Taipei 11529, Taiwan. FAU - Chen, Yu-Chen AU - Chen YC FAU - Hsiao, Han-Yun AU - Hsiao HY FAU - Chang, Chen AU - Chang C FAU - Chern, Yijuang AU - Chern Y LA - eng PT - Journal Article PT - Review DEP - 20130705 PL - England TA - J Biomed Sci JT - Journal of biomedical science JID - 9421567 SB - IM MH - Brain/*blood supply/metabolism MH - Brain Diseases/*pathology/physiopathology MH - *Cerebrovascular Circulation MH - Humans MH - Magnetic Resonance Imaging MH - Neovascularization, Pathologic/pathology PMC - PMC3729532 EDAT- 2013/07/09 06:00 MHDA- 2014/02/14 06:00 PMCR- 2013/07/05 CRDT- 2013/07/09 06:00 PHST- 2013/04/15 00:00 [received] PHST- 2013/06/17 00:00 [accepted] PHST- 2013/07/09 06:00 [entrez] PHST- 2013/07/09 06:00 [pubmed] PHST- 2014/02/14 06:00 [medline] PHST- 2013/07/05 00:00 [pmc-release] AID - 1423-0127-20-47 [pii] AID - 10.1186/1423-0127-20-47 [doi] PST - epublish SO - J Biomed Sci. 2013 Jul 5;20(1):47. doi: 10.1186/1423-0127-20-47.