PMID- 23830408
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20131121
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 27
IP  - 2
DP  - 2013 Apr-Jun
TI  - Anaphylactic reaction after the concomitant intravenous administration of 
      corticosteroids and gastroprotective drugs: two case reports.
PG  - 589-94
AB  - Corticosteroids are therapeutic drugs widely used in cases of allergic, 
      inflammatory and autoimmune diseases, but sometimes allergic hypersensitivity 
      reactions have been reported as a rare adverse effect of the corticosteroids 
      themselves. Moreover, glucocorticoids can induce gastric lesions; that’s why they 
      are sometimes administered intravenously together with some drugs such as proton 
      pump inhibitors (PPI) or inhibitors of histamine-2 receptors (antiH2) working as 
      gastric protectors. Although it is difficult to establish which drug was 
      responsible in case of hypersensitivity reactions, as hypersensitivity reactions 
      following to the use of PPI or anti-H2 have been already described in literature. 
      Here we describe two cases of immediate-type hypersensitivity triggered from the 
      administration of a corticosteroid plus a gastroprotective agent and the 
      diagnostic check up required in both these patients.
FAU - Ventura, M T
AU  - Ventura MT
FAU - Buquicchio, R
AU  - Buquicchio R
FAU - Cecere, R
AU  - Cecere R
FAU - Calogiuri, G
AU  - Calogiuri G
FAU - Cannito, C D
AU  - Cannito CD
FAU - De Donno, M
AU  - De Donno M
FAU - Maietta, G
AU  - Maietta G
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adrenal Cortex Hormones/*adverse effects
MH  - Adult
MH  - Anaphylaxis/*chemically induced/diagnosis
MH  - Basophils/physiology
MH  - Drug Hypersensitivity/*etiology
MH  - Female
MH  - Histamine H2 Antagonists/*adverse effects
MH  - Humans
MH  - Middle Aged
MH  - Omeprazole/adverse effects
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Skin Tests
EDAT- 2013/07/09 06:00
MHDA- 2013/09/05 06:00
CRDT- 2013/07/09 06:00
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
AID - 30 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2):589-94.