PMID- 23830818
OWN - NLM
STAT- MEDLINE
DCOM- 20140319
LR  - 20221207
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 106
IP  - 1-2
DP  - 2013 Sep
TI  - Predictive markers for carbamazepine and lamotrigine-induced maculopapular 
      exanthema in Han Chinese.
PG  - 296-300
LID - S0920-1211(13)00144-7 [pii]
LID - 10.1016/j.eplepsyres.2013.05.004 [doi]
AB  - The aims of this study were to clarify the possible associations of carbamazepine 
      (CBZ)- and lamotrigine (LTG)-induced maculopapular exanthema (MPE) with the human 
      leukocyte antigen (HLA) alleles in Chinese patients. A total of 249 subjects, 
      including 40 patients with CBZ-induced MPE (CBZ-MPE), 43 patients with 
      LTG-induced MPE (LTG-MPE), 52 CBZ-tolerant controls, 42 LTG-tolerant controls and 
      72 healthy controls, were included in this study. High-resolution HLA genotyping 
      was performed by a specific kit. Differences in the allele frequencies among the 
      groups were assessed. The allele frequencies of HLA-A*0201 and HLA-DRB1*1405 were 
      significantly higher (P=0.033 and P=0.003, respectively), but those of HLA-B*5801 
      and HLA-DRB1*0301 (P=0.037 and P=0.024, respectively) were lower in the CBZ-MPE 
      patients when compared with the CBZ-tolerant group. We also observed two 
      significantly increased alleles of HLA-A*3001 and HLA-B*1302 (P=0.013 and 
      P=0.013, respectively) and a decreased allele of HLA-A*3303 (P=0.048) in the 
      LTG-MPE patients when compared with those in the LTG-tolerant group. Our results 
      support the hypothesis that these HLA alleles contribute to the genetic 
      susceptibility to CBZ/LTG-MPE and may be valuable as potential biomarkers for 
      CBZ/LTG-MPE in Han Chinese.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Li, Li-Juan
AU  - Li LJ
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Hu, Fa-Yun
AU  - Hu FY
FAU - Wu, Xin-Tong
AU  - Wu XT
FAU - An, Dong-Mei
AU  - An DM
FAU - Yan, Bo
AU  - Yan B
FAU - Zhou, Dong
AU  - Zhou D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130705
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 0 (Triazines)
RN  - 33CM23913M (Carbamazepine)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Asian People
MH  - Biomarkers
MH  - Carbamazepine/*adverse effects/therapeutic use
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Drug Eruptions/*epidemiology/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-B15 Antigen/genetics
MH  - Humans
MH  - Lamotrigine
MH  - Male
MH  - Middle Aged
MH  - Parapsoriasis/*chemically induced/epidemiology/genetics
MH  - Predictive Value of Tests
MH  - Triazines/*adverse effects/therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - Carbamazepine
OT  - Human leukocyte antigen
OT  - Lamotrigine
OT  - Maculopapular exanthema
EDAT- 2013/07/09 06:00
MHDA- 2014/03/22 06:00
CRDT- 2013/07/09 06:00
PHST- 2013/01/30 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - S0920-1211(13)00144-7 [pii]
AID - 10.1016/j.eplepsyres.2013.05.004 [doi]
PST - ppublish
SO  - Epilepsy Res. 2013 Sep;106(1-2):296-300. doi: 10.1016/j.eplepsyres.2013.05.004. 
      Epub 2013 Jul 5.