PMID- 23831365 OWN - NLM STAT- MEDLINE DCOM- 20140806 LR - 20131209 IS - 1873-7064 (Electronic) IS - 0028-3908 (Linking) VI - 76 Pt C DP - 2014 Jan TI - BDNF mechanisms in late LTP formation: A synthesis and breakdown. PG - 664-76 LID - S0028-3908(13)00292-X [pii] LID - 10.1016/j.neuropharm.2013.06.024 [doi] AB - Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to understanding how the brain stores information in neural circuits and adapts to a changing environment. Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of stable, late phase long-term potentiation (L-LTP) at excitatory glutamatergic synapses in the adult brain. However, the mechanisms by which BDNF triggers L-LTP are controversial. Here, we distill and discuss the latest advances along three main lines: 1) TrkB receptor-coupled translational control underlying dendritic protein synthesis and L-LTP, 2) Mechanisms for BDNF-induced rescue of L-LTP when protein synthesis is blocked, and 3) BDNF-TrkB regulation of actin cytoskeletal dynamics in dendritic spines. Finally, we explore the inter-relationships between BDNF-regulated mechanisms, how these mechanisms contribute to different forms of L-LTP in the hippocampus and dentate gyrus, and outline outstanding issues for future research. This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'. CI - Copyright (c) 2013 Elsevier Ltd. All rights reserved. FAU - Panja, Debabrata AU - Panja D AD - Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway; KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway. FAU - Bramham, Clive R AU - Bramham CR LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20130702 PL - England TA - Neuropharmacology JT - Neuropharmacology JID - 0236217 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Tissue Proteins) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Dendrites MH - Long-Term Potentiation/drug effects/*physiology MH - Nerve Tissue Proteins/*metabolism MH - Neuronal Plasticity/drug effects MH - Protein Biosynthesis/drug effects/*physiology MH - Receptor, trkB/metabolism OTO - NOTNLM OT - 4EBP OT - AS OT - AS-ODN OT - Angelman syndrome OT - Arc OT - BDNF OT - Brain-derived neurotrophic factor (BDNF) OT - CA OT - CREB OT - CYFIP OT - Ca2- and calmodulin-dependent protein kinase II OT - CaMKII OT - Cytoskeletal dynamics OT - DG OT - DSCR OT - Down syndrome critical region OT - E-LTP OT - FMRP OT - GAB1 OT - GFP OT - Grb2-associated binding protein 1 OT - HFS OT - IEG OT - IP3 OT - L-LTP OT - LIM domain kinase 1 OT - LIMK1 OT - LTD OT - LTP OT - Long-term potentiation (LTP) OT - MAP OT - MAP-kinase interacting kinase OT - MAPK and ERK kinase, type 1/ 2 OT - MEK1/2 OT - MNK OT - PAK OT - PDZ OT - PI3-K OT - PKM OT - PLC OT - PRP OT - PSD OT - PSD95 OT - PSI OT - Protein synthesis OT - RISC OT - RNA-induced silencing complex OT - S6K OT - Synaptic plasticity OT - TBS OT - TORC OT - TSC OT - Translation control OT - TrkB OT - TrkB signaling OT - YFP OT - ZIP OT - activity-regulated cytoskeleton-associated protein OT - antisense oligodeoxynucleotide OT - brain-derived neurotrophic factor OT - cAMP response element-binding protein OT - cdk OT - cornu ammonis OT - cyclin-dependent kinase OT - cytoplasmic FMRP-interacting protein OT - dentate gyrus OT - eEF OT - eIF OT - eIF4E-binding protein OT - early-LTP OT - eukaryotic elongation factor OT - eukaryotic initiation factor OT - fragile X mental retardation protein OT - green-fluorescent protein OT - heterogenous nuclear ribonucleoprotein OT - high-frequency stimulation OT - hnRNP OT - immediate-early gene OT - inositol 1,4,5-trisphosphate OT - late-LTP OT - long-term depression OT - long-term potentiation OT - mTOR OT - mammalian target of rapamycin OT - miRNA OT - microRNA OT - microtubule-associated protein OT - p21-activated kinase OT - p70 S6 kinase OT - phosphatidylinositol 3-kinase OT - phospholipase C OT - plasticity-related protein OT - postsynaptic density OT - postsynaptic density protein 95 OT - postsynaptic density-95/Discs large/zona occludens-1 OT - protein kinase M OT - protein synthesis-inhibitor OT - target of rapamycin (TOR) complex OT - theta-burst stimulation OT - tropomyosin-related kinase B OT - tuberous sclerosis protein OT - yellow fluorescent protein OT - zeta inhibitory peptide EDAT- 2013/07/09 06:00 MHDA- 2014/08/07 06:00 CRDT- 2013/07/09 06:00 PHST- 2013/05/29 00:00 [received] PHST- 2013/06/21 00:00 [revised] PHST- 2013/06/23 00:00 [accepted] PHST- 2013/07/09 06:00 [entrez] PHST- 2013/07/09 06:00 [pubmed] PHST- 2014/08/07 06:00 [medline] AID - S0028-3908(13)00292-X [pii] AID - 10.1016/j.neuropharm.2013.06.024 [doi] PST - ppublish SO - Neuropharmacology. 2014 Jan;76 Pt C:664-76. doi: 10.1016/j.neuropharm.2013.06.024. Epub 2013 Jul 2.