PMID- 23831479
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20181202
IS  - 1872-7697 (Electronic)
IS  - 0167-8760 (Linking)
VI  - 90
IP  - 2
DP  - 2013 Nov
TI  - Effects of physiological aging on mismatch negativity: a meta-analysis.
PG  - 165-71
LID - S0167-8760(13)00197-9 [pii]
LID - 10.1016/j.ijpsycho.2013.06.026 [doi]
AB  - Mismatch negativity (MMN) is a promising window on how the functional integrity 
      of auditory sensory memory and change discrimination is modulated by age and 
      relevant clinical conditions. However, the effects of aging on MMN have remained 
      somewhat elusive, particularly at short interstimulus intervals (ISIs). We 
      performed a meta-analysis of peer-reviewed MMN studies that had targeted both 
      young and elderly adults to estimate the mean effect size. Nine studies, 
      consisting of 29 individual investigations, were included and the final total 
      study population consisted of 182 young and 165 elderly subjects. The effects of 
      different deviant types and duration of ISIs on the effect size were assessed. 
      The overall mean effect size was 0.63 (95% CI at 0.43-0.82). The effect sizes for 
      long ISI (>2s, effect size 0.68, 95% CI at 0.31-1.06) and short ISI (<2s, effect 
      size 0.61, 95% CI at 0.39-0.84) were both considered moderate. A further analysis 
      showed a prominent aging-related decrease in MMN responses to duration and 
      frequency changes at short ISIs. It was also interesting to note that the effect 
      size was about 25% larger for duration deviant condition compared to the 
      frequency deviant condition. In conclusion, a reduced MMN response to duration 
      and frequency deviants is a robust feature among the aged adults, which suggests 
      that there has been a decline in the functional integrity of central auditory 
      processing in this population.
CI  - (c) 2013.
FAU - Cheng, Chia-Hsiung
AU  - Cheng CH
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 
      Laboratory of Neurophysiology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Integrated Brain Research Laboratory, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
FAU - Hsu, Wan-Yu
AU  - Hsu WY
FAU - Lin, Yung-Yang
AU  - Lin YY
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20130704
PL  - Netherlands
TA  - Int J Psychophysiol
JT  - International journal of psychophysiology : official journal of the International 
      Organization of Psychophysiology
JID - 8406214
SB  - IM
MH  - Acoustic Stimulation
MH  - Adolescent
MH  - Adult
MH  - Aging/*physiology
MH  - Auditory Perception/*physiology
MH  - Contingent Negative Variation/*physiology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - MEDLINE/statistics & numerical data
MH  - Male
MH  - PubMed/statistics & numerical data
MH  - Young Adult
OTO - NOTNLM
OT  - Aging
OT  - Auditory sensory memory
OT  - Meta-analysis
OT  - Mismatch negativity (MMN)
OT  - Systematic review
EDAT- 2013/07/09 06:00
MHDA- 2014/06/10 06:00
CRDT- 2013/07/09 06:00
PHST- 2013/01/12 00:00 [received]
PHST- 2013/06/03 00:00 [revised]
PHST- 2013/06/29 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - S0167-8760(13)00197-9 [pii]
AID - 10.1016/j.ijpsycho.2013.06.026 [doi]
PST - ppublish
SO  - Int J Psychophysiol. 2013 Nov;90(2):165-71. doi: 10.1016/j.ijpsycho.2013.06.026. 
      Epub 2013 Jul 4.