PMID- 23831668
OWN - NLM
STAT- MEDLINE
DCOM- 20140528
LR  - 20220317
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 21
IP  - 11
DP  - 2013 Nov
TI  - Bone loss at subchondral plate in knee osteoarthritis patients with hypertension 
      and type 2 diabetes mellitus.
PG  - 1716-23
LID - S1063-4584(13)00863-7 [pii]
LID - 10.1016/j.joca.2013.06.027 [doi]
AB  - OBJECTIVES: This study aimed to characterize subchondral bone damages of knee 
      osteoarthritis (OA) patients in presence of the comorbidities, i.e., hypertension 
      and type 2 diabetes mellitus (T2DM). METHODS: A total of 43 patients with 
      advanced stage of primary knee OA were recruited, and tibial plateau specimens 
      were collected during surgery with informed consent. The specimens were processed 
      for micro-CT and histological examination to assess the severity of subchondral 
      bone damages. The presence of the comorbid disease, e.g., hypertension and T2DM, 
      and the data on covariates, such as the age, gender and body mass index (BMI), 
      were taken into account in a multi-variable linear regression model to explore 
      the potential effect of the comorbidities on subchondral bone damages in knee OA 
      after adjusting the covariates. RESULTS: As compared to 15 subjects without the 
      comorbidities, significant bone loss was observed at subchondral plate in 28 knee 
      OA patients with hypertension and T2DM, in terms of the lower bone mineral 
      density (BMD) (P = 0.034) and higher porosity (P = 0.032) on the medial portion 
      of tibial plateau. After adjusting the age, gender and BMI, the presence of 
      hypertension or T2DM was included in a regression model to explain in part the 
      decreased BMD (r(2) = 0.551, P = 0.004) and increased porosity (r(2) = 0.545, 
      P = 0.003) at subchondral plate in knee OA. CONCLUSION: Our findings suggest the 
      biological link between bone loss at subchondral bone plate in knee OA and the 
      comorbid diseases, i.e., hypertension and T2DM, which prompt the needs for a 
      large-scale cohort study to confirm the causality.
CI  - Copyright (c) 2013 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Wen, C Y
AU  - Wen CY
AD  - Department of Orthopaedics and Traumatology, LKS Faculty of Medicine, Hong Kong.
FAU - Chen, Y
AU  - Chen Y
FAU - Tang, H L
AU  - Tang HL
FAU - Yan, C H
AU  - Yan CH
FAU - Lu, W W
AU  - Lu WW
FAU - Chiu, K Y
AU  - Chiu KY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130704
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density/physiology
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*complications/pathology/physiopathology
MH  - Osteoporosis/*etiology/pathology/physiopathology
MH  - Porosity
MH  - Tibia/pathology/*physiopathology
MH  - X-Ray Microtomography/methods
OTO - NOTNLM
OT  - Hypertension
OT  - Microstructure
OT  - Osteoarthritis
OT  - Subchondral plate
OT  - Type 2 diabetes mellitus
EDAT- 2013/07/09 06:00
MHDA- 2014/05/29 06:00
CRDT- 2013/07/09 06:00
PHST- 2013/01/05 00:00 [received]
PHST- 2013/06/19 00:00 [revised]
PHST- 2013/06/27 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2014/05/29 06:00 [medline]
AID - S1063-4584(13)00863-7 [pii]
AID - 10.1016/j.joca.2013.06.027 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2013 Nov;21(11):1716-23. doi: 
      10.1016/j.joca.2013.06.027. Epub 2013 Jul 4.