PMID- 23833559
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130708
LR  - 20220408
IS  - 1226-2560 (Print)
IS  - 2093-8144 (Electronic)
IS  - 1226-2560 (Linking)
VI  - 22
IP  - 2
DP  - 2013 Jun
TI  - Glycyrrhizin attenuates kainic Acid-induced neuronal cell death in the mouse 
      hippocampus.
PG  - 107-15
LID - 10.5607/en.2013.22.2.107 [doi]
AB  - Glycyrrhizin (GL), a triterpene that is present in the roots and rhizomes of 
      licorice (Glycyrrhiza glabra), has been reported to have anti-inflammatory and 
      anti-viral effects. Recently, we demonstrated that GL produced the 
      neuroprotective effects with the suppression of microglia activation and 
      proinflammatory cytokine induction in the postischemic brain with middle cerebral 
      artery occlusion (MCAO) in rats and improved motor impairment and neurological 
      deficits. In the present study, we investigated whether GL has a beneficial 
      effect in kainic acid (KA)-induced neuronal death model. Intracerebroventricular 
      (i.c.v.) injection of 0.94 nmole (0.2 microg) of KA produced typical neuronal death 
      in both CA1 and CA3 regions of the hippocampus. In contrast, administration of GL 
      (10 mg/kg, i.p.) 30 min before KA administration significantly suppressed the 
      neuronal death, and this protective effect was more stronger at 50 mg/kg. 
      Moreover, the GL-mediated neuroprotection was accompanied with the suppression of 
      gliosis and induction of proinflammatory markers (COX-2, iNOS, and TNF-alpha). The 
      anti-inflammatory and anti-excitotoxic effects of GL were verified in LPS-treated 
      primary microglial cultures and in NMDA- or KA-treated primary cortical cultures. 
      Together these results suggest that GL confers the neuroprotection through the 
      mechanism of anti-inflammatory and anti-excitotoxic effects in KA-treated brain.
FAU - Luo, Lidan
AU  - Luo L
AD  - Department of Anatomy, Inha University School of Medicine, Incheon 400-712, 
      Korea.
FAU - Jin, Yinchuan
AU  - Jin Y
FAU - Kim, Il-Doo
AU  - Kim ID
FAU - Lee, Ja-Kyeong
AU  - Lee JK
LA  - eng
PT  - Journal Article
DEP - 20130627
PL  - Korea (South)
TA  - Exp Neurobiol
JT  - Experimental neurobiology
JID - 101278187
PMC - PMC3699671
OTO - NOTNLM
OT  - KA
OT  - anti-inflammation
OT  - glycyrrhizinic acid
OT  - neuroprotection
EDAT- 2013/07/09 06:00
MHDA- 2013/07/09 06:01
PMCR- 2013/06/01
CRDT- 2013/07/09 06:00
PHST- 2013/05/20 00:00 [received]
PHST- 2013/06/09 00:00 [revised]
PHST- 2013/06/10 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2013/07/09 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.5607/en.2013.22.2.107 [doi]
PST - ppublish
SO  - Exp Neurobiol. 2013 Jun;22(2):107-15. doi: 10.5607/en.2013.22.2.107. Epub 2013 
      Jun 27.