PMID- 23833737
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130708
LR  - 20220321
IS  - 2229-3485 (Print)
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 4
IP  - 2
DP  - 2013 Apr
TI  - Relationship of admission mean platelet volume, platelet distribution width and 
      white blood cells with ST resolution in patients with acute ST segment elevation 
      myocardial infarction treated with streptokinase without history of previous 
      cardiovascular surgery.
PG  - 125-9
LID - 10.4103/2229-3485.111792 [doi]
AB  - BACKGROUND: Mean platelet volume (MPV) and platelet distribution width (PDW), 
      markers of platelet reactivity, and white blood cell count (WBC-C), a marker of 
      inflammation, have been shown to be predictive of unfavorable outcomes among 
      survivors of ST elevation myocardial infarction (STEMI). we aimed to evaluate the 
      value of admission of MPV, PDW and WBC-C for the prediction of ST segment 
      resolution, in patient with acute STEMI treated with Streptokinase. MATERIALS AND 
      METHODS: This cross sectional study conducted on 280 patients with STEMI treated 
      with streptokinase, from August 2009 until August 2011, in Afshar cardiovascular 
      center, Yazd, Iran. Blood samples were obtained on admission in 280 patients with 
      STEMI. According to sum of ST segment resolution and Schroder's method, patients 
      divided two groups ((patients with ST resolution>/= 70% versus group with ST 
      resolution < 70%)). The best cut off value of MPV, PDW and WBC-C for prediction 
      of ST resolution (STR) were identified by using the receiver operating 
      characteristic curve. The optimum cut off level was determined by selecting 
      points of test value that provided the greatest sum of sensitivity and 
      specificity. RESULTS: Of 280 patients enrolled this study, 39.3% of the patients 
      with STR>/=70% and in 60.7% with STR<70% were found. Patients in the STR < 70% 
      group had higher admission MPV (10.6 +/- 0.8 vs. .9.5 +/- 0.8, P = 0.00) and higher 
      PDW (13.8 +/- 1.8 vs. 11.8 +/- 1.7, P = 0.00)and higher WBC-C (12.1 +/- 3.1 vs. 10.5 +/- 
      2.5, P = 0.00) compare with patients with ST resolution >/= 70%. The best cut off 
      value of MPV for predicting STR < 70%was 10/05 fl (sensitivity 71/8 and 
      specificity 80.9%) and for PDW was 12.85 fl (sensitivity 71.2% and specificity 
      83.6%) and for WBC-C was 12.65 x 1000 (sensitivity 42.9% and specificity 82.7%). 
      The greatest area under the receiver operating characteristic (ROC) curve and 
      greatest predicting value for ST resolution lower 70% was due to PDW (area = 
      0.812, P = 0/00). CONCLUSION: MPV, PDW and WBC-C at admission might be valuable 
      in the prediction of impaired STR and in planning the need for adjunctive therapy 
      to improve outcomes with STEMI treated with Streptokinase. We can speculate that 
      acute STEMI patients having MPV-PDW and WBC-C values above their's cut off 
      patients should be considered for stronger antiplatelet and helps anti 
      inflammation treatment to be able to attain a favorable ST resolution and better 
      clinical outcome.
FAU - Varasteh-Ravan, H R
AU  - Varasteh-Ravan HR
AD  - Department of Cardiovascular Disease, Yazd Cardiovascular Researches Center, 
      Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Ali-Hasan-Al-Saegh, Sadeq
AU  - Ali-Hasan-Al-Saegh S
FAU - Shokraneh, Shohre
AU  - Shokraneh S
FAU - Mozayan, Mohammad R
AU  - Mozayan MR
FAU - Karimi-Bondarabadi, Ali Akbar
AU  - Karimi-Bondarabadi AA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
EIN - Perspect Clin Res. 2017 Oct-Dec;8(4):198. Ali-Hassan-Sayegh, S [corrected to 
      Ali-Hasan-Al-Saegh, Sadeq]. PMID: 29109940
PMC - PMC3700326
OTO - NOTNLM
OT  - Mean platelet volume
OT  - ST segment resolution
OT  - platelet distribution width
OT  - white blood cell count
COIS- Conflict of Interest: None declared.
EDAT- 2013/07/09 06:00
MHDA- 2013/07/09 06:01
PMCR- 2013/04/01
CRDT- 2013/07/09 06:00
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2013/07/09 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - PCR-4-125 [pii]
AID - 10.4103/2229-3485.111792 [doi]
PST - ppublish
SO  - Perspect Clin Res. 2013 Apr;4(2):125-9. doi: 10.4103/2229-3485.111792.