PMID- 23834920 OWN - NLM STAT- MEDLINE DCOM- 20140225 LR - 20220317 IS - 1532-8414 (Electronic) IS - 1071-9164 (Linking) VI - 19 IP - 7 DP - 2013 Jul TI - Comparison of perfusion-metabolism mismatch in 99mTc-MIBI and 123I-BMIPP scintigraphy with cardiac magnetic resonance in patients with dilated cardiomyopathy. PG - 445-53 LID - S1071-9164(13)00158-9 [pii] LID - 10.1016/j.cardfail.2013.05.009 [doi] AB - BACKGROUND: Cardiac magnetic resonance (CMR) imaging is an established method of detecting myocardial fibrosis related to prognosis in patients with dilated cardiomyopathy (DCM). Recent studies have found that (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) and (123)I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) dual single-photon-emission computerized tomography (MIBI-BMIPP dual SPECT) can detect perfusion-metabolism mismatches. We compared MIBI-BMIPP dual SPECT with CMR findings and assessed their prognostic abilities to determine the significance of abnormal metabolism in patients with DCM. METHODS AND RESULTS: Fifty inpatients with DCM (age 58 +/- 12 y; 14 female) were assessed with the use of MIBI-BMIPP dual SPECT and CMR. Perfusion-metabolism mismatches were identified mainly at the left ventricular free wall, whereas late gadolinium enhancement (LGE) was evident mostly at the septal wall. During a median follow-up of 33 months, 9 patients developed cardiac events including death, heart failure, and fatal arrhythmia. Event-free survival rates were significantly lower for patients with LGE plus a mismatch than with other abnormalities (P = .001). Among clinical and imaging variables, LGE plus a mismatch was significantly associated with cardiac events (hazard ratio 7.9, 95% confidence interval 1.8-35.6; P = .007). CONCLUSIONS: Coexisting LGE and a perfusion-metabolism mismatch accurately predict future cardiac events in patients with DCM. CI - Copyright (c) 2013 Elsevier Inc. All rights reserved. FAU - Yoshida, Asuka AU - Yoshida A AD - Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan. FAU - Takano, Hitoshi AU - Takano H FAU - Asai, Kuniya AU - Asai K FAU - Yasutake, Masahiro AU - Yasutake M FAU - Amano, Yasuo AU - Amano Y FAU - Kumita, Shin-Ichiro AU - Kumita S FAU - Shimizu, Wataru AU - Shimizu W FAU - Mizuno, Kyoichi AU - Mizuno K LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - J Card Fail JT - Journal of cardiac failure JID - 9442138 RN - 0 (Fatty Acids) RN - 0 (Iodine Radioisotopes) RN - 0 (Iodobenzenes) RN - 0J7USQ749M (iodofiltic acid) RN - 971Z4W1S09 (Technetium Tc 99m Sestamibi) SB - IM MH - Adult MH - Aged MH - Cardiomyopathy, Dilated/diagnosis/*metabolism MH - Fatty Acids/*metabolism MH - Female MH - Follow-Up Studies MH - Humans MH - Iodine Radioisotopes/*metabolism MH - Iodobenzenes/*metabolism MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Perfusion Imaging/*methods MH - Retrospective Studies MH - Technetium Tc 99m Sestamibi/*metabolism MH - Tomography, Emission-Computed, Single-Photon/methods OTO - NOTNLM OT - Fatty acid metabolism OT - late gadolinium enhancement OT - single-photon-emission computerized tomography EDAT- 2013/07/10 06:00 MHDA- 2014/02/26 06:00 CRDT- 2013/07/10 06:00 PHST- 2013/01/28 00:00 [received] PHST- 2013/05/15 00:00 [revised] PHST- 2013/05/16 00:00 [accepted] PHST- 2013/07/10 06:00 [entrez] PHST- 2013/07/10 06:00 [pubmed] PHST- 2014/02/26 06:00 [medline] AID - S1071-9164(13)00158-9 [pii] AID - 10.1016/j.cardfail.2013.05.009 [doi] PST - ppublish SO - J Card Fail. 2013 Jul;19(7):445-53. doi: 10.1016/j.cardfail.2013.05.009.