PMID- 23836683
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20211021
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 591
IP  - 16
DP  - 2013 Aug 15
TI  - Aggressive behaviour and physiological responses to pheromones are strongly 
      impaired in mice deficient for the olfactory G-protein -subunit G8.
PG  - 3949-62
LID - 10.1113/jphysiol.2012.247528 [doi]
AB  - Heterotrimeric G-proteins are critical players in the transduction mechanisms 
      underlying odorant and pheromonal signalling. In the vomeronasal organ (VNO) of 
      the adult mouse, two different G-protein complexes have been identified. Galphaobeta2gamma8 
      is preferentially expressed in the basal neurons and coexpresses with type-2 
      vomeronasal pheromone receptors (V2Rs) whereas Galphai2beta2gamma2 is found in the apical 
      neurons and coexpresses with type-1 vomeronasal pheromone receptors (V1Rs). 
      V2R-expressing neurons project to the posterior accessory olfactory bulb (AOB) 
      whereas neurons expressing V1Rs send their axon to the anterior AOB. Ggamma8 is also 
      expressed in developing olfactory neurons where this protein is probably 
      associated with Go. Here, we generated mice with a targeted deletion of the Ggamma8 
      gene and investigated the behavioural effects and the physiological consequences 
      of this mutation. Ggamma8(-/-) mice show a normal development of the main olfactory 
      epithelium; moreover, they do not display major deficits in odour perception. In 
      contrast, the VNO undergoes a slow but remarkable loss of basal neurons starting 
      from the fourth postnatal week, with a 40% reduction of cells at 2 months and 70% 
      at 1 year. This loss is associated with a reduced early-gene expression in the 
      posterior AOB of mice stimulated with pheromones. More interestingly, the Ggamma8 
      deletion specifically leads to a reduced pheromone-mediated aggressiveness in 
      both males and females, all other socio-sexual behaviours remaining unaltered. 
      This study defines a specific role for Ggamma8 in maintenance of the neuronal 
      population of the VNO and in the mechanisms of pheromonal signalling that involve 
      the aggressive behaviour towards conspecifics.
FAU - Montani, Giorgia
AU  - Montani G
AD  - Department of Neuroscience, University of Parma, Italy.
FAU - Tonelli, Simone
AU  - Tonelli S
FAU - Sanghez, Valentina
AU  - Sanghez V
FAU - Ferrari, Pier Francesco
AU  - Ferrari PF
FAU - Palanza, Paola
AU  - Palanza P
FAU - Zimmer, Andreas
AU  - Zimmer A
FAU - Tirindelli, Roberto
AU  - Tirindelli R
LA  - eng
PT  - Journal Article
DEP - 20130708
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (GTP-Binding Protein gamma Subunits)
RN  - 0 (Pheromones)
RN  - 0 (Receptors, Pheromone)
SB  - IM
MH  - Aggression/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/*physiology
MH  - Female
MH  - GTP-Binding Protein gamma Subunits/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Neurons/physiology
MH  - Olfactory Bulb/physiology
MH  - Pheromones
MH  - Receptors, Pheromone/physiology
MH  - Recognition, Psychology
MH  - Vomeronasal Organ/*physiology
PMC - PMC3764639
EDAT- 2013/07/10 06:00
MHDA- 2014/03/04 06:00
PMCR- 2014/08/15
CRDT- 2013/07/10 06:00
PHST- 2013/07/10 06:00 [entrez]
PHST- 2013/07/10 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
PHST- 2014/08/15 00:00 [pmc-release]
AID - jphysiol.2012.247528 [pii]
AID - 10.1113/jphysiol.2012.247528 [doi]
PST - ppublish
SO  - J Physiol. 2013 Aug 15;591(16):3949-62. doi: 10.1113/jphysiol.2012.247528. Epub 
      2013 Jul 8.