PMID- 23836995
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130709
LR  - 20211021
IS  - 1178-6965 (Print)
IS  - 1178-6965 (Electronic)
IS  - 1178-6965 (Linking)
VI  - 6
DP  - 2013
TI  - Racial differences in the association of CD14 polymorphisms with serum total IgE 
      levels and allergen skin test reactivity.
PG  - 81-92
LID - 10.2147/JAA.S42695 [doi]
AB  - BACKGROUND: The CD14 C-159T single nucleotide polymorphism (SNP) has been 
      investigated widely as a candidate genetic locus in patients with allergic 
      disease. There are conflicting results for the association of the CD14 C-159T SNP 
      with total serum immunoglobulin E (IgE) levels and atopy. There are limited data 
      regarding the association of the CD14 C-159T SNP in subjects of African ancestry. 
      The aim of the study was to determine whether the C-159T SNP and other CD14 SNPs 
      (C1188G, C1341T) were associated with total serum IgE levels and with allergy 
      skin test results in nonatopic and atopic subjects; as well as in Caucasian and 
      African American subjects. METHODS: A total of 291 participants, 18-40 years old, 
      were screened to determine whether they were atopic and/or asthmatic. Analyses 
      were performed to determine the association between CD14 C-159T, C1188G, or 
      C1341T genotypes with serum IgE levels and with the number of positive skin tests 
      among Caucasian or African American subjects. RESULTS: We found no significant 
      association of serum total IgE level with CD14 C-159T, C1188G, or C1341T 
      genotypes within nonatopic or atopic subjects. Subjects with CD14-159 T alleles 
      had significantly more positive allergen skin tests than subjects without 
      CD14-159 T alleles (P = 0.0388). There was a significant association between the 
      CD14 1188 G allele, but not the CD14 1341 T allele, with the number of positive 
      skin-test results in Caucasians, but not in African Americans. CONCLUSION: These 
      results support a possible association between CD14 polymorphisms and atopy. 
      CD14-159 T or CD14 1188 G alleles were associated with atopic disease. For 
      subjects with CD14 1188 G alleles, the association with atopic disease was 
      stronger in Caucasians compared to African Americans.
FAU - Wang, Zongyao
AU  - Wang Z
AD  - Division of Pulmonary, Allergy and Critical Care Medicine.
FAU - Sundy, John S
AU  - Sundy JS
FAU - Foss, Catherine M
AU  - Foss CM
FAU - Barnhart, Huiman X
AU  - Barnhart HX
FAU - Palmer, Scott M
AU  - Palmer SM
FAU - Allgood, Sallie D
AU  - Allgood SD
FAU - Trudeau, Evan
AU  - Trudeau E
FAU - Alexander, Katie M
AU  - Alexander KM
FAU - Levesque, Marc C
AU  - Levesque MC
LA  - eng
PT  - Journal Article
DEP - 20130625
PL  - New Zealand
TA  - J Asthma Allergy
JT  - Journal of asthma and allergy
JID - 101543450
PMC - PMC3699133
OTO - NOTNLM
OT  - CD14-159T
OT  - IgE
OT  - LPS
OT  - SNP
OT  - SPT
OT  - endotoxin
OT  - lipopolysaccharide
OT  - single nucleotide polymorphism
OT  - skin prick test
OT  - total serum immunoglobulin E
EDAT- 2013/07/10 06:00
MHDA- 2013/07/10 06:01
PMCR- 2013/06/25
CRDT- 2013/07/10 06:00
PHST- 2013/07/10 06:00 [entrez]
PHST- 2013/07/10 06:00 [pubmed]
PHST- 2013/07/10 06:01 [medline]
PHST- 2013/06/25 00:00 [pmc-release]
AID - jaa-6-081 [pii]
AID - 10.2147/JAA.S42695 [doi]
PST - epublish
SO  - J Asthma Allergy. 2013 Jun 25;6:81-92. doi: 10.2147/JAA.S42695. Print 2013.