PMID- 23842103
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20220408
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 34
IP  - 2
DP  - 2014 Feb
TI  - Pentraxin 3 and other inflammatory factors in central retinal vein occlusion and 
      macular edema.
PG  - 352-9
LID - 10.1097/IAE.0b013e3182993d74 [doi]
AB  - PURPOSE: To evaluate the association between vitreous fluid levels of 
      inflammatory factors and macular edema in patients with central retinal vein 
      occlusion (CRVO). METHODS: In 30 CRVO patients with macular edema and 29 controls 
      with idiopathic macular hole, vitreous fluid samples were obtained during 
      vitreoretinal surgery. Retinal ischemia was evaluated from capillary nonperfusion 
      on fluorescein angiography. Macular edema was examined by optical coherence 
      tomography. RESULTS: Vitreous fluid levels of vascular endothelial growth factor 
      (VEGF), soluble VEGF receptor 2 (sVEGFR-2), soluble intercellular adhesion 
      molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic protein 1 
      (MCP-1), and pentraxin 3 (PTX3) were significantly higher in CRVO patients than 
      in macular hole patients. Vitreous fluid levels of VEGF, sICAM-1, IL-6, MCP-1, 
      and PTX3 were significantly correlated with the retinal thickness at the central 
      fovea. There were significant correlations between the vitreous fluid level of 
      VEGF and the levels of sICAM-1, IL-6, and MCP-1 in the CRVO patients. There was 
      also a significant correlation between sVEGFR-2 and PTX3 but not between VEGF and 
      PTX3. CONCLUSION: These findings suggest the importance of VEGF, its signal 
      transduction pathways, and the cytokine network and may be useful for 
      understanding the mechanism of macular edema in CRVO and developing new 
      treatments.
FAU - Noma, Hidetaka
AU  - Noma H
AD  - *Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical 
      University, Chiba, Japan; daggerDepartment of Ophthalmology, University of Tokyo 
      Graduate School of Medicine, Tokyo, Japan; double daggerDepartment of Ophthalmology, Eguchi 
      Eye Hospital, Hakodate, Japan; and  section signDepartment of Hygiene and Public Health II, 
      Tokyo Women's Medical University, Tokyo, Japan.
FAU - Mimura, Tatsuya
AU  - Mimura T
FAU - Masahara, Hidetaka
AU  - Masahara H
FAU - Shimada, Katsunori
AU  - Shimada K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid P-Component)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
SB  - IM
MH  - Acute-Phase Proteins/metabolism
MH  - Aged
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/metabolism
MH  - Cytokines/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-6/metabolism
MH  - Macular Edema/diagnosis/*metabolism
MH  - Male
MH  - Retinal Vein Occlusion/diagnosis/*metabolism
MH  - Serum Amyloid P-Component/*metabolism
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/*metabolism
MH  - Vascular Endothelial Growth Factor Receptor-2/*metabolism
MH  - Vitrectomy
MH  - Vitreous Body/*metabolism
EDAT- 2013/07/12 06:00
MHDA- 2014/07/17 06:00
CRDT- 2013/07/12 06:00
PHST- 2013/07/12 06:00 [entrez]
PHST- 2013/07/12 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - 10.1097/IAE.0b013e3182993d74 [doi]
PST - ppublish
SO  - Retina. 2014 Feb;34(2):352-9. doi: 10.1097/IAE.0b013e3182993d74.