PMID- 23843150
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20211021
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Print)
IS  - 0736-0266 (Linking)
VI  - 31
IP  - 10
DP  - 2013 Oct
TI  - Replication of chronic abnormal cartilage loading by medial meniscus 
      destabilization for modeling osteoarthritis in the rabbit knee in vivo.
PG  - 1555-60
LID - 10.1002/jor.22393 [doi]
AB  - Medial meniscus destabilization (MMD) is a surgical insult technique for modeling 
      osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal 
      joints in vivo. The present study aimed to characterize the immediate 
      biomechanical effects (ex vivo) and short-term histological consequences (in 
      vivo) of MMD in the rabbit knee. In a compressive loading test, contact stress 
      distribution in the medial compartment was measured in eight cadaver rabbit 
      knees, initially with all major joint structures uninjured (Baseline), after MMD, 
      and finally after total medial meniscectomy (TMM). Similarly, the effects on 
      sagittal joint stability were determined in an anterior-posterior drawer test. 
      These biomechanical (ex vivo) data indicated that both MMD and TMM caused 
      significant (p < 0.001), distinct (>1.5-fold) elevation of peak local contact 
      stress in the medial compartment, while leaving whole-joint stability nearly 
      unchanged. Histological consequences in vivo were assessed in a short-term 
      (8-week) survival series of MMD or TMM (five animals for each group), and both 
      caused moderate cartilage degeneration in the medial compartment. The MMD insult, 
      which is feasible through posterior arthrotomy alone, is as effective as TMM for 
      modeling injurious-level chronic abnormal cartilage loading in the rabbit knee 
      medial compartment in vivo, while minimizing potential confounding effects from 
      whole-joint instability.
CI  - Copyright (c) 2013 Orthopaedic Research Society.
FAU - Arunakul, Marut
AU  - Arunakul M
AD  - Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics 
      Laboratory, University of Iowa, 2181 Westlawn, Iowa City, Iowa, 52242-1100, USA.
FAU - Tochigi, Yuki
AU  - Tochigi Y
FAU - Goetz, Jessica E
AU  - Goetz JE
FAU - Diestelmeier, Bryce W
AU  - Diestelmeier BW
FAU - Heiner, Anneliese D
AU  - Heiner AD
FAU - Rudert, James
AU  - Rudert J
FAU - Fredericks, Douglas C
AU  - Fredericks DC
FAU - Brown, Thomas D
AU  - Brown TD
FAU - McKinley, Todd O
AU  - McKinley TO
LA  - eng
GR  - P50 AR055533/AR/NIAMS NIH HHS/United States
GR  - P50AR055533/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130710
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena/physiology
MH  - Chronic Disease
MH  - *Disease Models, Animal
MH  - Joint Instability/pathology/physiopathology/surgery
MH  - Menisci, Tibial/pathology/*physiopathology/surgery
MH  - Osteoarthritis, Knee/pathology/*physiopathology/surgery
MH  - *Rabbits
MH  - Stifle/pathology/physiopathology/surgery
MH  - Stress, Mechanical
MH  - Tibia/pathology/physiopathology
MH  - Weight-Bearing/*physiology
PMC - PMC5113956
MID - NIHMS697474
OTO - NOTNLM
OT  - contact stress
OT  - meniscus
OT  - post-traumatic osteoarthritis
OT  - rabbit knee
OT  - survival animal model
EDAT- 2013/07/12 06:00
MHDA- 2013/10/29 06:00
PMCR- 2016/11/17
CRDT- 2013/07/12 06:00
PHST- 2012/10/16 00:00 [received]
PHST- 2013/04/29 00:00 [accepted]
PHST- 2013/07/12 06:00 [entrez]
PHST- 2013/07/12 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
PHST- 2016/11/17 00:00 [pmc-release]
AID - 10.1002/jor.22393 [doi]
PST - ppublish
SO  - J Orthop Res. 2013 Oct;31(10):1555-60. doi: 10.1002/jor.22393. Epub 2013 Jul 10.