PMID- 23844192
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 7
DP  - 2013
TI  - Regional brain structural abnormality in meal-related functional dyspepsia 
      patients: a voxel-based morphometry study.
PG  - e68383
LID - 10.1371/journal.pone.0068383 [doi]
LID - e68383
AB  - BACKGROUND AND AIMS: Brain dysfunction in functional dyspepsia (FD) has been 
      identified by multiple neuroimaging studies. This study aims to investigate the 
      regional gray matter density (GMD) changes in meal-related FD patients and their 
      correlations with clinical variables, and to explore the possible influence of 
      the emotional state on FD patients's brain structures. METHODS: Fifty 
      meal-related FD patients and forty healthy subjects (HS) were included and 
      underwent a structural magnetic resonance imaging scan. Voxel-based morphometry 
      analysis was employed to identify the cerebral structure alterations in 
      meal-related FD patients. Regional GMD changes' correlations with the symptoms 
      and their durations, respectively, have been analyzed. RESULTS: Compared to the 
      HS, the meal-related FD patients showed a decreased GMD in the bilateral 
      precentral gyrus, medial prefrontal cortex (MPFC), anterior cingulate cortex 
      (ACC) and midcingulate cortex (MCC), left orbitofrontal cortex (OFC) and right 
      insula (p<0.05, FWE Corrected, Cluster size>50). After controlling for anxiety 
      and depression, the meal-related FD patients showed a decreased GMD in the 
      bilateral middle frontal gyrus, left MCC, right precentral gyrus and insula 
      (p<0.05, FWE Corrected, Cluster size>50). Before controlling psychological 
      factors, the GMD decreases in the ACC were negatively associated with the symptom 
      scores of the Nepean Dyspepsia Index (NDI) (r = -0.354, p = 0.048, Bonferroni 
      correction) and the duration of FD (r = -0.398, p = 0.02, Bonferroni correction) 
      respectively. CONCLUSIONS: The regional GMD of meal-related FD patients, 
      especially in the regions of the homeostatic afferent processing network 
      significantly differed from that of the HS, and the psychological factors might 
      be one of the essential factors significantly affecting the regional brain 
      structure of meal-related FD patients.
FAU - Zeng, Fang
AU  - Zeng F
AD  - The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Qin, Wei
AU  - Qin W
FAU - Yang, Yue
AU  - Yang Y
FAU - Zhang, Danhua
AU  - Zhang D
FAU - Liu, Jixin
AU  - Liu J
FAU - Zhou, Guangyu
AU  - Zhou G
FAU - Sun, Jinbo
AU  - Sun J
FAU - Lu, Shengfeng
AU  - Lu S
FAU - Tang, Yong
AU  - Tang Y
FAU - Chen, Yuan
AU  - Chen Y
FAU - Lan, Lei
AU  - Lan L
FAU - Yu, Shuguang
AU  - Yu S
FAU - Li, Ying
AU  - Li Y
FAU - Gao, Xin
AU  - Gao X
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Tian, Jie
AU  - Tian J
FAU - Liang, Fanrong
AU  - Liang F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130702
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Anxiety/physiopathology
MH  - Brain/pathology/*physiopathology
MH  - Brain Mapping
MH  - Depression/physiopathology
MH  - Dyspepsia/pathology/*physiopathology
MH  - Female
MH  - Frontal Lobe/pathology/physiopathology
MH  - Gyrus Cinguli/pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/pathology/*physiopathology
MH  - Prefrontal Cortex/pathology/physiopathology
MH  - Young Adult
PMC - PMC3699561
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/07/12 06:00
MHDA- 2014/02/08 06:00
PMCR- 2013/07/02
CRDT- 2013/07/12 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/07/12 06:00 [entrez]
PHST- 2013/07/12 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
PHST- 2013/07/02 00:00 [pmc-release]
AID - PONE-D-12-17683 [pii]
AID - 10.1371/journal.pone.0068383 [doi]
PST - epublish
SO  - PLoS One. 2013 Jul 2;8(7):e68383. doi: 10.1371/journal.pone.0068383. Print 2013.