PMID- 23844266
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130711
LR  - 20211021
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 6
IP  - 6
DP  - 2013
TI  - Brain-derived neurotrophic factor is up-regulated in severe acute cauda equina 
      syndrome dog model.
PG  - 431-7
AB  - To determine the level of brain-derived neurotrophic factor (BDNF) in 
      experimental dog model of severe acute cauda equina syndrome, which was induced 
      by multiple cauda equina constrictions throughout the entire lumbar (L), sacral 
      (S) and coccygeal (Co) spinal cord and their central processes of the dorsal root 
      ganglia neurons. Adult male mongrel dogs were randomly divided into 2 groups. The 
      experiment group (n=4) was subjected to multiple cauda equina constrictions. The 
      control group (n=4) was subjected to cauda equina exposure without constrictions. 
      Level of BDNF in the spinal cord and the dorsal root ganglion cells (L7, S1-S3) 
      was assessed 48 hours after multiple constrictions by immunohistochemical and 
      histopathological analyses. 48 hours after multiple constrictions of cauda 
      equina, up-regulation of BDNF within lumbosacral (L7-S3) spinal cord and dorsal 
      root ganglion was observed in experimental group as compared to control group. 
      Our result suggests that BDNF might play a role in the inflammatory and 
      neuropathic pain as a result of multiple cauda equina constrictions. Regulation 
      of BDNF level could potentially provide a therapy for treating cauda equina 
      syndrome.
FAU - Tan, Jun-Ming
AU  - Tan JM
AD  - Center of Trauma Repair and Reconstruction of Chinese PLA and Department of 
      Orthopedics of the 98th Hospital of Chinese PLA Huzhou 313000, Zhejiang Province, 
      China.
FAU - Wu, Jianxin
AU  - Wu J
FAU - Shi, Jian-Gang
AU  - Shi JG
FAU - Shi, Guo-Dong
AU  - Shi GD
FAU - Liu, Yan-Ling
AU  - Liu YL
FAU - Liu, Xiao-Hong
AU  - Liu XH
FAU - Wan, Chao-Yang
AU  - Wan CY
FAU - Chen, De-Chun
AU  - Chen DC
FAU - Xing, Shun-Min
AU  - Xing SM
FAU - Shen, Lian-Bing
AU  - Shen LB
FAU - Jia, Lian-Shun
AU  - Jia LS
FAU - Ye, Xiao-Jian
AU  - Ye XJ
FAU - Li, Jia-Shun
AU  - Li JS
LA  - eng
PT  - Journal Article
DEP - 20130626
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC3703113
OTO - NOTNLM
OT  - Cauda equina syndrome (CES)
OT  - brain-derived neurotrophic factor (BDNF)
OT  - dorsal root ganglion (DRG)
OT  - multiple cauda equina constrictions (MCEC)
OT  - neurotrophic factors (NFs)
EDAT- 2013/07/12 06:00
MHDA- 2013/07/12 06:01
PMCR- 2013/06/26
CRDT- 2013/07/12 06:00
PHST- 2013/05/14 00:00 [received]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/07/12 06:00 [entrez]
PHST- 2013/07/12 06:00 [pubmed]
PHST- 2013/07/12 06:01 [medline]
PHST- 2013/06/26 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2013 Jun 26;6(6):431-7. Print 2013.