PMID- 23844985 OWN - NLM STAT- MEDLINE DCOM- 20140331 LR - 20220409 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 29 IP - 9 DP - 2013 Sep TI - Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea. PG - 817-20 LID - 10.3109/09513590.2013.813472 [doi] AB - INTRODUCTION: Functional hypothalamic amenorrhea (FHA) is a non organic, secondary amenorrhea related to gonadotropin-releasing hormone pulsatile secretion impairment. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays an important role in the growth, development, maintenance and function of several neuronal systems. AIM OF THE STUDY: The aim of the study was the evaluation of plasma BDNF concentrations in patients with the diagnosis of FHA. MATERIAL AND METHODS: We studied 85 subjects diagnosed with FHA who were compared with 10 healthy, eumenorrheic controls with normal body mass index. Plasma BDNF and serum luteinizing hormone, follicle-stimulating hormone and estradiol (E2) concentrations were measured by immunoenzymatic method (enzyme-linked immunosorbent assay). RESULTS: Significantly lower concentration of plasma BDNF was found in FHA patients (196.31 +/- 35.26 pg/ml) in comparison to healthy controls (407.20 +/- 25.71 pg/ml; p < 0.0001). In the control group, there was a strong positive correlation between plasma BDNF and serum E2 concentrations (r = 0.92, p = 0.0001) but in FHA group it was not found. CONCLUSIONS: Role of BDNF in FHA is not yet fully understood. There could be found studies concerning plasma BDNF concentrations in humans and animals in the literature. However, our study is one of the first projects which describes decreased plasma BDNF concentration in patients with diagnosed FHA. Therefore, further studies on BDNF in FHA should clarify the role of this peptide. FAU - Podfigurna-Stopa, Agnieszka AU - Podfigurna-Stopa A AD - Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Casarosa, Elena AU - Casarosa E FAU - Luisi, Michele AU - Luisi M FAU - Czyzyk, Adam AU - Czyzyk A FAU - Meczekalski, Blazej AU - Meczekalski B FAU - Genazzani, Andrea Riccardo AU - Genazzani AR LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130711 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 4TI98Z838E (Estradiol) RN - 9002-67-9 (Luteinizing Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM EIN - Gynecol Endocrinol. 2014 Jan;30(1):82 MH - Adolescent MH - Adult MH - Amenorrhea/*blood/*etiology MH - Body Mass Index MH - Brain-Derived Neurotrophic Factor/*blood MH - Case-Control Studies MH - Estradiol/blood MH - Female MH - Follicle Stimulating Hormone/blood MH - Humans MH - Hypothalamic Diseases/*blood/*complications MH - Luteinizing Hormone/blood MH - Young Adult EDAT- 2013/07/13 06:00 MHDA- 2014/04/01 06:00 CRDT- 2013/07/13 06:00 PHST- 2013/07/13 06:00 [entrez] PHST- 2013/07/13 06:00 [pubmed] PHST- 2014/04/01 06:00 [medline] AID - 10.3109/09513590.2013.813472 [doi] PST - ppublish SO - Gynecol Endocrinol. 2013 Sep;29(9):817-20. doi: 10.3109/09513590.2013.813472. Epub 2013 Jul 11.