PMID- 23845215
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20131025
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 62
IP  - 11
DP  - 2013 Nov
TI  - Prenatal omega 3 fatty acid supplementation to a micronutrient imbalanced diet 
      protects brain neurotrophins in both the cortex and hippocampus in the adult rat 
      offspring.
PG  - 1607-22
LID - S0026-0495(13)00182-0 [pii]
LID - 10.1016/j.metabol.2013.06.002 [doi]
AB  - OBJECTIVE: Our earlier studies show that maternal diets imbalanced in 
      micronutrients like folic acid and vitamin B12 reduced brain docosahexaenoic acid 
      (DHA) and brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) 
      in the offspring at birth and postnatal d21. This study followed the offspring 
      till 3 months to examine the hypothesis that impaired brain neurotrophins at 
      birth and d21 due to altered maternal micronutrients can be reversed by prenatal 
      omega 3 fatty acid but not a postnatal control diet leading to altered cognition 
      in adult life. MATERIALS AND METHODS: Pregnant rats were divided into control and 
      five treatment groups at two levels of folic acid (normal and excess folate) in 
      the presence and absence of vitamin B12 (NFBD, EFB and EFBD). Omega 3 fatty acid 
      supplementation was given to the vitamin B12 deficient groups (NFBDO and EFBDO). 
      Following delivery, 8 dams from each group were shifted to control and remaining 
      continued on same diet. RESULTS: Imbalance in maternal micronutrients up to 
      3months decreased DHA, BDNF and NGF in cortex and only BDNF in the hippocampus 
      and impaired cognitive performance. Postnatal control diet normalized BDNF in the 
      cortex but not the hippocampus and also altered cognitive performance. Prenatal 
      omega 3 fatty acid supplementation normalized DHA, BDNF and NGF while long term 
      supplementation was not beneficial only when micronutrients were imbalanced. 
      CONCLUSION: Patterns established at birth are not totally reversible by postnatal 
      diets and give clues for planning intervention studies for improving brain 
      functioning and cognitive abilities.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Sable, Pratiksha S
AU  - Sable PS
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth Deemed University, Pune 411043, India.
FAU - Kale, Anvita A
AU  - Kale AA
FAU - Joshi, Sadhana R
AU  - Joshi SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130709
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Micronutrients)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Brain/anatomy & histology
MH  - Brain-Derived Neurotrophic Factor/blood/drug effects/*metabolism
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Cognition/*drug effects
MH  - *Diet
MH  - Dietary Supplements
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Female
MH  - Folic Acid/administration & dosage/metabolism
MH  - Folic Acid Deficiency/blood/*metabolism
MH  - Hippocampus/drug effects/*metabolism
MH  - Homocysteine/blood
MH  - Maze Learning/drug effects
MH  - Micronutrients/administration & dosage/*deficiency/metabolism
MH  - Nerve Growth Factor/blood/drug effects/*metabolism
MH  - Organ Size
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Vitamin B 12/administration & dosage/metabolism
MH  - Vitamin B 12 Deficiency/blood/*metabolism
OTO - NOTNLM
OT  - AA
OT  - Arachidonic Acid
OT  - BDNF
OT  - Brain Derived Neurotrophic Factor
OT  - Brain derived neurotrophic factor
OT  - Cognition
OT  - DHA
OT  - Developmental Origins of Health and Disease
OT  - DoHad
OT  - Docosahexaenoic Acid
OT  - NGF
OT  - Nerve Growth Factor
EDAT- 2013/07/13 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/07/13 06:00
PHST- 2013/02/13 00:00 [received]
PHST- 2013/05/28 00:00 [revised]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0026-0495(13)00182-0 [pii]
AID - 10.1016/j.metabol.2013.06.002 [doi]
PST - ppublish
SO  - Metabolism. 2013 Nov;62(11):1607-22. doi: 10.1016/j.metabol.2013.06.002. Epub 
      2013 Jul 9.