PMID- 23845391
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20191210
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 933
DP  - 2013 Aug 15
TI  - Development of a simple method for simultaneous determination of nine subclasses 
      of non-steroidal anti-inflammatory drugs in milk and dairy products by 
      ultra-performance liquid chromatography with tandem mass spectrometry.
PG  - 15-23
LID - S1570-0232(13)00339-5 [pii]
LID - 10.1016/j.jchromb.2013.06.025 [doi]
AB  - A multi-residue analysis method for simultaneous determination of nine subclasses 
      of non-steroidal anti-inflammatory drugs (NSAIDs) in milk and dairy products by 
      ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has 
      been established. The sample was initially extracted and deproteinized with 
      ascorbic acid buffer (0.01M, pH 3) and acetonitrile-ethyl acetate mixture, 
      followed by centrifugation and evaporation, then reconstituted with 
      acetonitrile-0.1% formic acid (1+1, v/v). After removal of lipid material by 
      n-hexane, the sample was analyzed by UPLC-MS/MS with electro-spray ionization 
      (ESI) interface in Multiple Reaction Monitoring (MRM) mode. The range of limits 
      of detection (LODs) and limits of quantification (LOQs) were 0.03-0.30mug/kg and 
      0.10-1.00mug/kg, respectively. The recoveries in milk, milk powder, yogurt, 
      processed cheese and milk beverage ranged from 61.7% to 117%, and the relative 
      standard deviations (RSDs) were less than 17.9% at three spiked levels (1, 10 and 
      100 times of the LOQ). Matrix effects were also investigated and it was 
      determined the signals of the analytes were suppressed from 9.4% to 76.6% in 
      processed cheese. The proposed method was also applied to incurred sample 
      analysis. The results proved that this method was suitable for the simultaneous 
      determination of nine subclasses of NSAIDs residues in milk and dairy products.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Peng, Tao
AU  - Peng T
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
FAU - Zhu, Ai-Ling
AU  - Zhu AL
FAU - Zhou, Yue-Ning
AU  - Zhou YN
FAU - Hu, Ting
AU  - Hu T
FAU - Yue, Zhen-Feng
AU  - Yue ZF
FAU - Chen, Dong-Dong
AU  - Chen DD
FAU - Wang, Guo-Min
AU  - Wang GM
FAU - Kang, Jian
AU  - Kang J
FAU - Fan, Chun-lin
AU  - Fan CL
FAU - Chen, Ying
AU  - Chen Y
FAU - Jiang, Hai-Yang
AU  - Jiang HY
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130621
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemistry
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Dairy Products/*analysis
MH  - Drug Residues/*chemistry
MH  - Food Contamination/analysis
MH  - Limit of Detection
MH  - Milk/*chemistry
MH  - Spectrometry, Mass, Electrospray Ionization/methods
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Dairy products
OT  - Milk
OT  - Multi-residue analysis
OT  - NSAIDs
OT  - UPLC-MS/MS
EDAT- 2013/07/13 06:00
MHDA- 2014/02/01 06:00
CRDT- 2013/07/13 06:00
PHST- 2013/02/22 00:00 [received]
PHST- 2013/06/07 00:00 [revised]
PHST- 2013/06/14 00:00 [accepted]
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
AID - S1570-0232(13)00339-5 [pii]
AID - 10.1016/j.jchromb.2013.06.025 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 15;933:15-23. doi: 
      10.1016/j.jchromb.2013.06.025. Epub 2013 Jun 21.