PMID- 23847079
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20130712
IS  - 1612-1880 (Electronic)
IS  - 1612-1872 (Linking)
VI  - 10
IP  - 7
DP  - 2013 Jul
TI  - Chemical composition and antimicrobial activity of the essential oil of Stachys 
      officinalis (L.) Trevis. (Lamiaceae).
PG  - 1335-49
LID - 10.1002/cbdv.201200332 [doi]
AB  - Characterization by GC-FID and GC/MS analyses of the Stachys officinalis (L.) 
      Trevis. essential oil obtained by hydrodistillation of the aerial parts allowed 
      the identification of 190 components that represented 97.9% of the total oil 
      content. The main constituents identified were germacrene D (19.9%), 
      beta-caryophyllene (14.1%), and alpha-humulene (7.5%). Terpenoids were by far 
      predominant (89.4%), with sesquiterpene hydrocarbons (69.1%) and oxygenated 
      sesquiterpenes (14.8%) being the most abundant compounds detected in the oil. 
      Based on the present and previously published results, multivariate statistical 
      comparison of the chemical composition of the essential oils was performed within 
      the species. Principal component analysis (PCA) and agglomerative hierarchical 
      clustering (AHC) of the data on the volatile profiles of S. officinalis taxa 
      revealed no pronounced differences among the samples originated from the Balkan 
      Peninsula. Additionally, the oil was screened for in vitro antibacterial and 
      antifungal activity using the broth microdilution assay. The oil's best 
      antimicrobial activities were obtained against the mold Aspergillus niger 
      (minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations of 2.5 and 
      5.0 mg/ml, resp.) and the yeast Candida albicans (MIC and MFC of 5.0 mg/ml).
CI  - Copyright (c) 2013 Verlag Helvetica Chimica Acta AG, Zurich.
FAU - Lazarevic, Jelena S
AU  - Lazarevic JS
AD  - Department of Chemistry, Faculty of Medical Sciences, University of Nis, Bul. dr 
      Zorana Ethindica 81, RS-18000 Nis. jelena217@yahoo.com
FAU - Dordevic, Aleksandra S
AU  - Dordevic AS
FAU - Kitic, Dusanka V
AU  - Kitic DV
FAU - Zlatkovic, Bojan K
AU  - Zlatkovic BK
FAU - Stojanovic, Gordana S
AU  - Stojanovic GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Chem Biodivers
JT  - Chemistry & biodiversity
JID - 101197449
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Oils, Volatile)
SB  - IM
MH  - Anti-Infective Agents/*chemistry/isolation & purification/pharmacology
MH  - Aspergillus niger/drug effects
MH  - Candida albicans/drug effects
MH  - Cluster Analysis
MH  - Gas Chromatography-Mass Spectrometry
MH  - Microbial Sensitivity Tests
MH  - Oils, Volatile/*analysis/isolation & purification/pharmacology
MH  - Plant Components, Aerial/chemistry
MH  - Principal Component Analysis
MH  - Stachys/*chemistry
OTO - NOTNLM
OT  - Agglomerative hierarchical clustering (AHC)
OT  - Antimicrobial activity
OT  - Essential oils
OT  - Multivariate analysis (MVA)
OT  - Principal component analysis (PCA)
OT  - Stachys officinalis
EDAT- 2013/07/13 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/07/13 06:00
PHST- 2012/09/22 00:00 [received]
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 10.1002/cbdv.201200332 [doi]
PST - ppublish
SO  - Chem Biodivers. 2013 Jul;10(7):1335-49. doi: 10.1002/cbdv.201200332.