PMID- 23847253
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20221102
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 269
IP  - 2
DP  - 2013 Nov
TI  - Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging: T2 
      versus T2.
PG  - 387-95
AB  - PURPOSE: To evaluate T2 and T2* changes in acute reperfused hemorrhagic and 
      nonhemorrhagic myocardial infarctions and to determine which technique is more 
      suitable in the detection of intramyocardial hemorrhage at 1.5 T. MATERIALS AND 
      METHODS: Patient studies were approved by the institutional review board and were 
      HIPAA compliant. Patients (n = 14, three women) with first ST-elevation 
      myocardial infarction underwent cardiac magnetic resonance (MR) imaging 3 days 
      after angioplasty. T2* maps, T2 short inversion time inversion-recovery (STIR) 
      images, and late gadolinium enhancement (LGE) images were acquired. Animal 
      studies were approved by the institutional animal care and use committee. Canines 
      (n = 20) were subjected to ischemia-reperfusion injury, and cardiac MR imaging 
      was performed 5 days after reperfusion. T2* and T2 maps and T2 STIR and LGE 
      images were acquired. Repeated-measures analysis of variance or the Friedman test 
      was used to compare T2 and T2* changes in patients with hemorrhagic infarctions 
      and those with nonhemorrhagic infarctions. RESULTS: Relative to remote 
      myocardium, mean T2* of hemorrhagic infarctions was 54% +/- 13 (standard deviation) 
      lower in patients (15.9 msec +/- 4.5 vs 35.2 msec +/- 2.1, P < .001) and 40% +/- 10 
      lower in canines (23.0 msec +/- 4.0 vs 39.3 msec +/- 2.5, P < .001). Mean T2* of 
      nonhemorrhagic infarctions was marginally elevated by 6% +/- 2.5 (37.8 msec +/- 2.5, 
      P = .021) in patients and by 8% +/- 5 (44.6 msec +/- 4.8, P = .012) in canines. In 
      contrast, mean T2 STIR signal intensity (SI) of both hemorrhagic infarctions and 
      nonhemorrhagic infarctions was higher than that in remote myocardium both in 
      patients (hemorrhagic: 37% +/- 19, P < .001; nonhemorrhagic: 78% +/- 27, P < .001) 
      and in canines (hemorrhagic: 42% +/- 22, P < .001; nonhemorrhagic: 65% +/- 22, P < 
      .001). Consistent with STIR SI findings, mean T2 of both hemorrhagic (62.0 msec +/- 
      4.9) and nonhemorrhagic (71.7 msec +/- 7.3) infarctions in canines was elevated 
      relative to mean T2 of remote myocardium (52.1 msec +/- 4.8) by 18% +/- 9 and 38% +/- 
      13, respectively (P < .001 for both). CONCLUSION: T2* cardiac MR imaging is more 
      suitable than T2 cardiac MR imaging in the detection and characterization of 
      acute reperfusion myocardial hemorrhage. SUPPLEMENTAL MATERIAL: 
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13122397/-/DC1.
CI  - RSNA, 2013
FAU - Kali, Avinash
AU  - Kali A
AD  - Biomedical Imaging Research Institute, Department of Biomedical Sciences, and 
      Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, PACT Bldg-Suite 800, 
      8700 Beverly Blvd, Los Angeles, Calif 90048; Department of Biomedical 
      Engineering, Northwestern University, Evanston, Ill; Department of Biomedical 
      Engineering and Department of Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Calif; Quebec Heart and Lung Institute, 
      Laval University, Quebec City, Quebec, Canada.
FAU - Tang, Richard L Q
AU  - Tang RL
FAU - Kumar, Andreas
AU  - Kumar A
FAU - Min, James K
AU  - Min JK
FAU - Dharmakumar, Rohan
AU  - Dharmakumar R
LA  - eng
GR  - R01 HL091989/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130711
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Angioplasty, Balloon, Coronary
MH  - Animals
MH  - Contrast Media
MH  - Dogs
MH  - Female
MH  - Hemorrhage/*diagnosis
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/therapy
MH  - Reperfusion Injury/*diagnosis
PMC - PMC3807083
EDAT- 2013/07/13 06:00
MHDA- 2014/01/10 06:00
PMCR- 2013/11/02
CRDT- 2013/07/13 06:00
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
PHST- 2013/11/02 00:00 [pmc-release]
AID - radiol.13122397 [pii]
AID - 10.1148/radiology.13122397 [doi]
PST - ppublish
SO  - Radiology. 2013 Nov;269(2):387-95. doi: 10.1148/radiology.13122397. Epub 2013 Jul 
      11.