PMID- 23847429
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130712
LR  - 20220408
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 6
DP  - 2013
TI  - Effects of proton pump inhibitors and electrolyte disturbances on arrhythmias.
PG  - 515-8
LID - 10.2147/IJGM.S46932 [doi]
AB  - Several case reports have been written regarding the relationship between the use 
      of proton pump inhibitors (PPI) and hypomagnesemia. Some of these reported cases 
      have electrocardiogram abnormalities where electrolytes deficiencies were the 
      contributing factor for these events. This study investigates the correlation 
      between different arrhythmias and the use of PPI and hypomagnesaemia incidence. 
      Four-hundred and twenty-one patients admitted to the critical care unit with 
      unstable angina, non-ST elevation myocardial infarction, and ST-elevation 
      myocardial infarction were included in this study. One-hundred and eighty-four 
      patients (43.8%) received PPI and 237 patients (51.16%) did not, magnesium levels 
      were low (<1.8 mg/dL) in 95 patients (22.5%), and 167 patients (39.6%) developed 
      arrhythmias. The P-values for the regression coefficient association for the use 
      of PPI and the level of magnesium were P = 1.31e(-29) and P = 8e(-102), 
      respectively. The P-values indicate that there is a statistically significant 
      association between the PPI use, magnesium levels, and the occurrence of 
      cardiovascular events, with a strong correlation factor of 0.817. Patients 
      receiving PPIs should be followed closely for magnesium deficiency, especially if 
      they experience acute cardiovascular events, because this may contribute to 
      worsening arrhythmias and further complications.
FAU - El-Charabaty, Elie
AU  - El-Charabaty E
AD  - Department of Medicine, Staten Island University Hospital, Staten Island, NY, 
      USA.
FAU - Saifan, Chadi
AU  - Saifan C
FAU - Abdallah, Mokhtar
AU  - Abdallah M
FAU - Naboush, Ali
AU  - Naboush A
FAU - Glass, Daniel
AU  - Glass D
FAU - Azzi, Georges
AU  - Azzi G
FAU - Azzi, Yorg
AU  - Azzi Y
FAU - Khan, Ahsan
AU  - Khan A
FAU - Baydoun, Hassan
AU  - Baydoun H
FAU - Rondla, Chetana
AU  - Rondla C
FAU - Parekh, Ninad
AU  - Parekh N
FAU - El-Sayegh, Suzanne
AU  - El-Sayegh S
LA  - eng
PT  - Journal Article
DEP - 20130628
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3700779
OTO - NOTNLM
OT  - cardiac arrhythmias
OT  - electrolyte disturbances
OT  - medications side effects
EDAT- 2013/07/13 06:00
MHDA- 2013/07/13 06:01
PMCR- 2013/06/28
CRDT- 2013/07/13 06:00
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2013/07/13 06:01 [medline]
PHST- 2013/06/28 00:00 [pmc-release]
AID - ijgm-6-515 [pii]
AID - 10.2147/IJGM.S46932 [doi]
PST - epublish
SO  - Int J Gen Med. 2013 Jun 28;6:515-8. doi: 10.2147/IJGM.S46932. Print 2013.