PMID- 23847551
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130712
LR  - 20211021
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 4
DP  - 2013
TI  - Exploring epigenetic regulation of fear memory and biomarkers associated with 
      post-traumatic stress disorder.
PG  - 62
LID - 10.3389/fpsyt.2013.00062 [doi]
LID - 62
AB  - This review examines recent work on epigenetic mechanisms underlying animal 
      models of fear learning as well as its translational implications in disorders of 
      fear regulation, such as Post-traumatic Stress Disorder (PTSD). Specifically, we 
      will examine work outlining roles of differential histone acetylation and 
      DNA-methylation associated with consolidation, reconsolidation, and extinction in 
      Pavlovian fear paradigms. We then focus on the numerous studies examining the 
      epigenetic modifications of the Brain-derived neurotrophin factor (BDNF) pathway 
      and the extension of these findings from animal models to recent work in human 
      clinical populations. We will also review recently published data on FKBP5 
      regulation of glucocorticoid receptor function, and how this is modulated in 
      animal models of PTSD and in human clinical populations via epigenetic 
      mechanisms. As glucocorticoid regulation of memory consolidation is well 
      established in fear models, we examine how these recent data contribute to our 
      broader understanding of fear memory formation. The combined recent progress in 
      epigenetic modulation of memory with the advances in fear neurobiology suggest 
      that this area may be critical to progress in our understanding of fear-related 
      disorders with implications for new approaches to treatment and prevention.
FAU - Maddox, Stephanie A
AU  - Maddox SA
AD  - Yerkes National Primate Research Center , Atlanta, GA , USA ; Department of 
      Psychiatry and Behavioral Sciences, Emory University School of Medicine , 
      Atlanta, GA , USA.
FAU - Schafe, Glenn E
AU  - Schafe GE
FAU - Ressler, Kerry J
AU  - Ressler KJ
LA  - eng
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - R01 MH071537/MH/NIMH NIH HHS/United States
GR  - R01 MH094757/MH/NIMH NIH HHS/United States
GR  - R01 MH096764/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20130701
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC3697031
OTO - NOTNLM
OT  - PTSD
OT  - amygdala
OT  - biomarkers
OT  - consolidation
OT  - extinction
OT  - fear memory
OT  - reconsolidation
EDAT- 2013/07/13 06:00
MHDA- 2013/07/13 06:01
PMCR- 2013/07/01
CRDT- 2013/07/13 06:00
PHST- 2013/04/30 00:00 [received]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2013/07/13 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 10.3389/fpsyt.2013.00062 [doi]
PST - epublish
SO  - Front Psychiatry. 2013 Jul 1;4:62. doi: 10.3389/fpsyt.2013.00062. eCollection 
      2013.