PMID- 23847552
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130712
LR  - 20220310
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 4
DP  - 2013
TI  - Relationship between Brain-Derived Neurotrophic Factor and Schneiderian First 
      Rank Symptoms in Antipsychotic-Naive Schizophrenia.
PG  - 64
LID - 10.3389/fpsyt.2013.00064 [doi]
LID - 64
AB  - Neurodevelopmental aberrations influenced by neurotrophic factors are among the 
      important paradigms to understand schizophrenia pathogenesis. Among various 
      neurotrophic factors, Brain-Derived Neurotrophic Factor (BDNF) is strongly 
      implicated by previous research studies. Evaluating co-morbidity free, 
      antipsychotic-naive schizophrenia patients for BDNF levels and examining the 
      correlates of this factor with symptoms might facilitate elucidation of its 
      pathogenetic role without confounds of potential influencing factors. In this 
      study, 59 co-morbidity free, antipsychotic-naive schizophrenia patients were 
      compared with 60 healthy controls for serum BDNF levels. In addition, the 
      relationship between Schneiderian First Rank Symptoms (FRS) and BDNF level in 
      patients was examined. As a group, schizophrenia patients (28.8 +/- 11.7 ng/mL) had 
      significantly lower serum BDNF than healthy controls (34.9 +/- 8.2 ng/mL) after 
      controlling for the potential confounding effects of age and sex (F = 7.8; 
      p = 0.006). Further analyses revealed FRS status to have significant effect on 
      plasma BDNF after controlling for the potential confounding effects of age and 
      sex (F = 4.5; p = 0.01). Follow-up post hoc analyses revealed FRS(+) patients to 
      have significant deficit in plasma BDNF level in comparison with healthy controls 
      (p = 0.002); however, FRS(-) patients did not differ from healthy controls 
      (p = 0.38). Our study observations add further support to the role for BDNF in 
      schizophrenia pathogenesis and suggest a potential novel link between deficient 
      BDNF and FRS.
FAU - Kalmady, Sunil Vasu
AU  - Kalmady SV
AD  - Department of Psychiatry, The Schizophrenia Clinic, National Institute of Mental 
      Health and Neuro Sciences , Bangalore , India ; Translational Psychiatry 
      Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, 
      National Institute of Mental Health and Neuro Sciences , Bangalore , India.
FAU - Venkatasubramanian, Ganesan
AU  - Venkatasubramanian G
FAU - Shivakumar, Venkataram
AU  - Shivakumar V
FAU - Jose, Dania
AU  - Jose D
FAU - Ravi, Vasanthapuram
AU  - Ravi V
FAU - Gangadhar, Bangalore N
AU  - Gangadhar BN
LA  - eng
PT  - Journal Article
DEP - 20130702
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC3698453
OTO - NOTNLM
OT  - BDNF
OT  - Schneiderian first rank symptoms
OT  - antipsychotic-naive
OT  - schizophrenia
EDAT- 2013/07/13 06:00
MHDA- 2013/07/13 06:01
PMCR- 2013/07/02
CRDT- 2013/07/13 06:00
PHST- 2013/01/22 00:00 [received]
PHST- 2013/06/17 00:00 [accepted]
PHST- 2013/07/13 06:00 [entrez]
PHST- 2013/07/13 06:00 [pubmed]
PHST- 2013/07/13 06:01 [medline]
PHST- 2013/07/02 00:00 [pmc-release]
AID - 10.3389/fpsyt.2013.00064 [doi]
PST - epublish
SO  - Front Psychiatry. 2013 Jul 2;4:64. doi: 10.3389/fpsyt.2013.00064. eCollection 
      2013.