PMID- 23849050
OWN - NLM
STAT- MEDLINE
DCOM- 20131001
LR  - 20221207
IS  - 2210-7762 (Print)
VI  - 206
IP  - 5
DP  - 2013 May
TI  - Differences in the cytogenetic alteration profiles of diffuse large B-cell 
      lymphoma among Chinese and American patients.
PG  - 183-90
LID - S2210-7762(13)00053-7 [pii]
LID - 10.1016/j.cancergen.2013.05.001 [doi]
AB  - To study the similarities and differences of cytogenetic alterations in diffuse 
      large B-cell lymphoma (DLBCL) between Asian and Caucasian patients, we compared 
      the cytogenetic profiles of Chinese and American DLBCL cases by analyzing 
      conventional karyotypes and select fluorescence in situ hybridization (FISH) 
      findings. We used interphase FISH analyses to determine the incidence of the 
      t(14;18) and BCL6 and MYC rearrangements. Immunohistochemical analysis was used 
      to categorize the lymphomas into the germinal center B-cell-like (GCB) or 
      non-GCB-DLBCL subtypes, according to the Hans algorithm. Our data suggested that 
      Chinese patients had cytogenetic profiles for GCB-DLBCL that differed from those 
      of their American counterparts; specifically, the Chinese GCB patients exhibited 
      greater frequencies of BCL6 rearrangements and gains of 1q and 11q but lower 
      incidence of the t(14;18). Non-GCB-DLBCL in both the Chinese and American 
      patients was characterized by recurrent gains of 3/3q and 18/18q. The incidences 
      of both BCL6 rearrangement and t(14;18) were similar in Chinese and American 
      non-GCB-DLBCL cases.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Pathology and Microbiology, University of Nebraska Medical Center, 
      Omaha, NE, USA.
FAU - Dave, Bhavana J
AU  - Dave BJ
FAU - Zhu, Xiongzeng
AU  - Zhu X
FAU - Chan, Wing C
AU  - Chan WC
FAU - Iqbal, Javeed
AU  - Iqbal J
FAU - Sanger, Warren G
AU  - Sanger WG
FAU - Fu, Kai
AU  - Fu K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (BCL6 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - *Gene Rearrangement
MH  - *Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Karyotype
MH  - Lymphoma, Large B-Cell, Diffuse/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - White People/genetics
OTO - NOTNLM
OT  - Diffuse large B-cell lymphoma
OT  - Hans algorithm
OT  - activated B-cell-like DLBCL
OT  - germinal center B-cell-like DLBCL
OT  - immunohistochemistry
EDAT- 2013/07/16 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/07/16 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2013/04/17 00:00 [revised]
PHST- 2013/05/03 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S2210-7762(13)00053-7 [pii]
AID - 10.1016/j.cancergen.2013.05.001 [doi]
PST - ppublish
SO  - Cancer Genet. 2013 May;206(5):183-90. doi: 10.1016/j.cancergen.2013.05.001.