PMID- 23849257
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20130902
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 80
IP  - 6
DP  - 2013 Oct 1
TI  - Thyroid hormone concentrations in foals affected by perinatal asphyxia syndrome.
PG  - 624-9
LID - S0093-691X(13)00232-X [pii]
LID - 10.1016/j.theriogenology.2013.06.003 [doi]
AB  - The hypothalamus-pituitary-thyroid axis has specific functions, mostly related to 
      metabolic activities, cell differentiation, and development. To the authors' 
      knowledge, there are no studies about thyroid hormone (TH) concentrations in 
      foals affected by perinatal asphyxia syndrome (PAS). Hence, the aims of the study 
      are (1) to evaluate plasma TH concentrations (T3 and T4) in healthy foals during 
      the first 7 days of life; (2) to evaluate plasma TH concentration (T3 and T4) in 
      critically ill foals affected by PAS during the first 7 days of hospitalization; 
      and (3) to compare TH concentrations between surviving and nonsurviving 
      critically ill foals. Forty-five Standardbred foals were enrolled in this 
      prospective observational study: 21 healthy foals (group 1) and 24 foals affected 
      by PAS (group 2). Jugular blood samples were collected within 10 minutes from 
      birth/admission and every 24 hours for 7 days (t0-t7). TH concentrations were 
      analyzed by RIA. In both groups, T3 concentration was significantly lower at t4, 
      t5, t6, and t7 compared with t1 (P < 0.05), and T4 concentration was 
      significantly higher at birth than at all other time points (P < 0.01). No 
      differences were found in TH concentrations at admission between surviving (n = 
      20) and nonsurviving (n = 4) foals. Statistical comparison between healthy and 
      PAS foals divided into age groups showed significantly lower TH concentrations at 
      t0 in PAS foals <12 hours old at admission (P < 0.01). In conclusion, PAS may 
      cause lower T3 and T4 concentrations in affected foals than in age-matched 
      healthy foals, as reported for other systemic illnesses, such as sepsis and 
      prematurity. TH concentrations showed no prognostic value, which maybe due to the 
      small number of nonsurviving foals in this study. Further studies are needed to 
      find out if thyroid replacement therapy could be useful in the treatment of 
      critically ill foals affected by PAS.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Pirrone, Alessandro
AU  - Pirrone A
AD  - Department of Veterinary Medical Sciences, Universita di Bologna, Bologna, Italy. 
      alessandro.pirrone2@unibo.it
FAU - Panzani, Sara
AU  - Panzani S
FAU - Govoni, Nadia
AU  - Govoni N
FAU - Castagnetti, Carolina
AU  - Castagnetti C
FAU - Veronesi, Maria Cristina
AU  - Veronesi MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20130709
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*blood
MH  - Asphyxia/*blood/diagnosis/mortality/veterinary
MH  - Horse Diseases/*blood/diagnosis/mortality
MH  - Horses/*blood
MH  - Prognosis
MH  - Sepsis/blood/diagnosis/veterinary
MH  - Thyroid Hormones/*blood
OTO - NOTNLM
OT  - Foal
OT  - Perinatal asphyxia syndrome
OT  - Thyroid hormones
EDAT- 2013/07/16 06:00
MHDA- 2014/04/01 06:00
CRDT- 2013/07/16 06:00
PHST- 2012/12/18 00:00 [received]
PHST- 2013/06/03 00:00 [revised]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
AID - S0093-691X(13)00232-X [pii]
AID - 10.1016/j.theriogenology.2013.06.003 [doi]
PST - ppublish
SO  - Theriogenology. 2013 Oct 1;80(6):624-9. doi: 
      10.1016/j.theriogenology.2013.06.003. Epub 2013 Jul 9.