PMID- 23850066
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20211021
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 38
IP  - 8
DP  - 2013 Aug
TI  - Menin: a scaffold protein that controls gene expression and cell signaling.
PG  - 394-402
LID - S0968-0004(13)00091-1 [pii]
LID - 10.1016/j.tibs.2013.05.005 [doi]
AB  - The protein menin is encoded by the MEN1 gene, which is mutated in patients with 
      multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a 
      tumor suppressor in endocrine organs, it is required for leukemic transformation 
      in mouse models. Menin possesses these dichotomous functions probably because it 
      can both positively and negatively regulate gene expression, as well as interact 
      with a multitude of proteins with diverse functions. Here, we review the recent 
      progress in understanding the molecular mechanisms by which menin functions. The 
      crystal structures of menin with different binding partners reveal that menin is 
      a key scaffold protein that functionally crosstalks with various partners to 
      regulate gene transcription and interplay with multiple signaling pathways.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Matkar, Smita
AU  - Matkar S
AD  - Department of Cancer Biology, Abramson Family Cancer Research Institute, Abramson 
      Cancer Center, the University of Pennsylvania Perelman School of Medicine, 421 
      Curie Boulevard, Philadelphia, PA 19104, USA.
FAU - Thiel, Austin
AU  - Thiel A
FAU - Hua, Xianxin
AU  - Hua X
LA  - eng
GR  - R01 DK085121/DK/NIDDK NIH HHS/United States
GR  - R01 DK097555/DK/NIDDK NIH HHS/United States
GR  - R01-DK085121/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130710
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Down-Regulation
MH  - Endocrine Glands/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - *Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/genetics/metabolism
MH  - Mutation
MH  - Neoplasm Proteins/chemistry/genetics/metabolism
MH  - Nuclear Matrix/*metabolism
MH  - Protein Conformation
MH  - Protein Interaction Domains and Motifs
MH  - Proto-Oncogene Proteins/chemistry/genetics/*metabolism
MH  - *Signal Transduction
PMC - PMC3741089
MID - NIHMS490863
OTO - NOTNLM
OT  - cell signaling
OT  - gene transcription
OT  - menin
OT  - scaffold protein
EDAT- 2013/07/16 06:00
MHDA- 2014/02/04 06:00
PMCR- 2014/08/01
CRDT- 2013/07/16 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/05/22 00:00 [revised]
PHST- 2013/05/31 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S0968-0004(13)00091-1 [pii]
AID - 10.1016/j.tibs.2013.05.005 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2013 Aug;38(8):394-402. doi: 10.1016/j.tibs.2013.05.005. Epub 
      2013 Jul 10.