PMID- 23850250
OWN - NLM
STAT- MEDLINE
DCOM- 20140423
LR  - 20160518
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 6
IP  - 8
DP  - 2013 Aug
TI  - Fat deposition in dilated cardiomyopathy assessed by CMR.
PG  - 889-98
LID - S1936-878X(13)00454-3 [pii]
LID - 10.1016/j.jcmg.2013.04.010 [doi]
AB  - OBJECTIVES: The aim of this study was to prospectively investigate the prevalence 
      of fat deposition in idiopathic dilated cardiomyopathy (DCM) by fat-water 
      separation imaging. An auxiliary aim was to determine the relationship between 
      left ventricular (LV) fat deposition and characteristic myocardial fibrosis, as 
      well as cardiac functional parameters. BACKGROUND: Idiopathic DCM remains the 
      most common cause of heart failure in young people referred for cardiac 
      transplantation; little is known about the clinical value of fat deposition in 
      DCM. METHODS: A total of 124 patients with DCM were studied after written 
      informed consent was obtained. The magnetic resonance imaging scan protocols 
      included a series of short-axis LV cine imaging for functional analysis, 
      fat-water separation imaging, and late gadolinium enhancement (LGE) imaging. Fat 
      deposition and fibrosis location were compared to the scar regions on LGE images 
      using a 17-segment model. Statistical comparisons of LV global functional 
      parameters, fibrosis volumes, and fat deposition were carried out using the 
      Pearson correlation, Student t test, and multiple regressions. RESULTS: The 
      patients had a 41.9% (52 of 124) prevalence of positive LGE, and 12.9% (16 of 
      124) fat deposition prevalence was found in this DCM cohort. The patients with 
      fat deposition had larger LV end-diastolic volume (LVEDV) index (140.8 +/- 20.2 
      ml/m(2) vs. 123.4 +/- 15.8 ml/m(2); p < 0.01), larger LV end-systolic volume 
      (LVESV) index (111.3 +/- 19.2 ml/m(2) vs. 87.0 +/- 20.3 ml/m(2); p < 0.01), and 
      decreased LV ejection fraction (LVEF) (21.1 +/- 7.1% vs. 30.0 +/- 10.7%; p < 0.01). 
      Higher volumes of LGE were found in the group with myocardial fat deposition 
      (18.39 +/- 9.0 ml vs. 13.40 +/- 6.54 ml; p = 0.001), as well as a higher percentage 
      of LGE/LV mass (19.11 +/- 7.78% vs. 13.60 +/- 4.58%; p = 0.000). The volume of fat 
      deposition was correlated with scar volume, LVEF, LVEDV index, and LVESV index. 
      CONCLUSIONS: Fat deposition is a common phenomenon in DCM, and it is associated 
      with DCM characteristics such as fibrosis volume and LV function.
CI  - Copyright (c) 2013 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Lu, Minjie
AU  - Lu M
AD  - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, Peoples Republic of China.
FAU - Zhao, Shihua
AU  - Zhao S
FAU - Jiang, Shiliang
AU  - Jiang S
FAU - Yin, Gang
AU  - Yin G
FAU - Wang, Cheng
AU  - Wang C
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Liu, Qiong
AU  - Liu Q
FAU - Cheng, Huaibing
AU  - Cheng H
FAU - Ma, Ning
AU  - Ma N
FAU - Zhao, Tao
AU  - Zhao T
FAU - Chen, Xiuyu
AU  - Chen X
FAU - Huang, Jinghan
AU  - Huang J
FAU - Zou, Yubao
AU  - Zou Y
FAU - Song, Lei
AU  - Song L
FAU - He, Zuoxiang
AU  - He Z
FAU - An, Jing
AU  - An J
FAU - Renate, Jerecic
AU  - Renate J
FAU - Xue, Hui
AU  - Xue H
FAU - Shah, Saurabh
AU  - Shah S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130710
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2014 Apr;7(4):432-3. PMID: 24742896
CIN - JACC Cardiovasc Imaging. 2014 Apr;7(4):433. PMID: 24742897
MH  - Adipose Tissue/*pathology
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*pathology/physiopathology
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - CO
OT  - DCM
OT  - LGE
OT  - LV
OT  - LVEDV
OT  - LVEF
OT  - LVESV
OT  - LVM
OT  - MRI
OT  - cardiac output
OT  - dilated cardiomyopathy
OT  - fat deposition
OT  - late gadolinium enhancement
OT  - left ventricle/ventricular
OT  - left ventricular ejection fraction
OT  - left ventricular end-diastolic volume
OT  - left ventricular end-systolic volume
OT  - left ventricular mass
OT  - water-fat separation imaging
EDAT- 2013/07/16 06:00
MHDA- 2014/04/24 06:00
CRDT- 2013/07/16 06:00
PHST- 2012/11/01 00:00 [received]
PHST- 2013/04/05 00:00 [revised]
PHST- 2013/04/12 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/04/24 06:00 [medline]
AID - S1936-878X(13)00454-3 [pii]
AID - 10.1016/j.jcmg.2013.04.010 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2013 Aug;6(8):889-98. doi: 10.1016/j.jcmg.2013.04.010. 
      Epub 2013 Jul 10.