PMID- 23850356
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20171116
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 253
DP  - 2013 Sep 15
TI  - Neotrofin reverses the effects of chronic unpredictable mild stress on behavior 
      via regulating BDNF, PSD-95 and synaptophysin expression in rat.
PG  - 48-53
LID - S0166-4328(13)00413-0 [pii]
LID - 10.1016/j.bbr.2013.07.014 [doi]
AB  - Depression is one of the most common neuropsychiatric disorders and has been 
      associated with a wide range of neuronal structural changes in brain regions. 
      Neotrofin, a neurotrophin agonist, has been demonstrated to exhibit 
      neuroprotection in various in vivo and in vitro studies. The present study aimed 
      to investigate the neuroprotective and ameliorating effects of neotrofin 
      treatment in a rat model of chronic unpredictable mild stress (CUMS) induced 
      depression. The results showed that CUMS was effective in producing 
      depression-like behavior in rats as indicated by decreased responses in the 
      sucrose preference test, and locomotor activity in the open-field test. Moreover, 
      the expression of brain-derived neurotrophic factor (BDNF), PSD-95 and 
      synaptophysin were decreased in the amygdala of CUMS rats. Chronic administration 
      of neotrofin (60mg/kg, i.p., 5 weeks) significantly ameliorated all these 
      behavioral and biochemical alterations associated with CUMS induced depression, 
      which demonstrated that the expression changes of BDNF, PSD-95 and synaptophysin 
      were correlated with the depression-like behaviors of CUMS rats. Taken together, 
      the results of the present study highlight that neotrofin exhibits 
      neuroprotective and antidepressant-like effects against CUMS induced depression, 
      and suggest a possible mechanism for this protection via changes in synaptic 
      plasticity within the amygdala. These findings reveal the therapeutic potential 
      of neotrofin for use in clinical trials in the treatment of neuronal 
      deterioration in depression.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Luo, Junxia
AU  - Luo J
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province 250012, PR China.
FAU - Zhang, Lin
AU  - Zhang L
FAU - Ning, Nannan
AU  - Ning N
FAU - Jiang, Hong
AU  - Jiang H
FAU - Yu, Shu Yan
AU  - Yu SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130711
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Aminobenzoates)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, rat)
RN  - 0 (Hypoxanthines)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Synaptophysin)
RN  - 138117-50-7 (4-((3-(1,6-dihyro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic 
      acid)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Aminobenzoates/*pharmacology
MH  - Amygdala/drug effects/metabolism
MH  - Animals
MH  - *Antidepressive Agents
MH  - Behavior, Animal/*drug effects
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Chronic Disease
MH  - Data Interpretation, Statistical
MH  - Disks Large Homolog 4 Protein
MH  - Food Preferences/drug effects
MH  - Hypoxanthines/*pharmacology
MH  - Intracellular Signaling Peptides and Proteins/*biosynthesis
MH  - Male
MH  - Membrane Proteins/*biosynthesis
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity/drug effects
MH  - *Neuroprotective Agents
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*psychology
MH  - Sucrose
MH  - Synaptophysin/*biosynthesis
OTO - NOTNLM
OT  - AD
OT  - ANOVA
OT  - Alzheimer's disease
OT  - Amygdala
OT  - BDNF
OT  - CUMS
OT  - Chronic unpredictable mild stress
OT  - Depression
OT  - NGF
OT  - NT-3
OT  - NT-4
OT  - Neotrofin
OT  - PSD-95
OT  - analysis of variance
OT  - brain derived neurotrophic factor
OT  - chronic unpredictable mild stress
OT  - nerve growth factor
OT  - neurotrophin-3
OT  - neurotrophin-4
OT  - postsynaptic density protein 95
EDAT- 2013/07/16 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/07/16 06:00
PHST- 2013/06/11 00:00 [received]
PHST- 2013/07/04 00:00 [revised]
PHST- 2013/07/06 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - S0166-4328(13)00413-0 [pii]
AID - 10.1016/j.bbr.2013.07.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Sep 15;253:48-53. doi: 10.1016/j.bbr.2013.07.014. Epub 2013 
      Jul 11.