PMID- 23850968
OWN - NLM
STAT- MEDLINE
DCOM- 20140627
LR  - 20211203
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 31
IP  - 7
DP  - 2013 Nov
TI  - Resveratrol improves postnatal hippocampal neurogenesis and brain derived 
      neurotrophic factor in prenatally stressed rats.
PG  - 580-5
LID - S0736-5748(13)00107-X [pii]
LID - 10.1016/j.ijdevneu.2013.06.010 [doi]
AB  - Prenatal stress induced neuronal dysfunction is multifactorial, including 
      suppressed neurogenesis in developing brain. Resveratrol is known to exert its 
      neuroprotective potential by enhancing neurogenesis. But the efficacy of 
      resveratrol against prenatal stress was not addressed in detail. Hence in the 
      present study we evaluated the neuroprotective action of resveratrol on prenatal 
      stress-induced impaired neurogenesis. Pregnant rats were subjected to restraint 
      stress during early or late gestational period. Another sets of rats received 
      resveratrol during entire gestational period along with early or late gestational 
      stress. The study parameters included neuronal assay of doublecortin positive 
      neurons (DCX +ve) and brain derived neurotrophic factor (BDNF) estimations in 
      40th postnatal day rat brain. Both early and late gestational stress resulted in 
      significant decrease in generation of new born neurons and BDNF expression in 
      hippocampus. The decrease in number of DCX +ve neurons and hippocampal BDNF 
      expression was more profound in the offspring who received late gestational 
      stress compared to early gestational stress. Resveratrol treatment has improved 
      the expression of DCX +ve neurons and BDNF expression. These data suggest the 
      neuroprotective efficacy of resveratrol against prenatal stress induced impaired 
      neurogenesis.
CI  - Copyright (c) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Madhyastha, Sampath
AU  - Madhyastha S
AD  - Department of Anatomy, Kasturba Medical College, Manipal University, Mangalore, 
      India. Electronic address: Sampath.m@manipal.edu.
FAU - Sekhar, Sudhanshu
AU  - Sekhar S
FAU - Rao, Gayathri
AU  - Rao G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130710
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/*metabolism/physiopathology
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurogenesis/*drug effects
MH  - Neuropeptides/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/drug therapy/etiology/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Restraint, Physical/adverse effects
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
OTO - NOTNLM
OT  - BDNF
OT  - Doublecortin
OT  - Hippocampus
OT  - Neurogenesis
OT  - Prenatal stress
OT  - Resveratrol
EDAT- 2013/07/16 06:00
MHDA- 2014/06/28 06:00
CRDT- 2013/07/16 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/06/27 00:00 [revised]
PHST- 2013/06/27 00:00 [accepted]
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/06/28 06:00 [medline]
AID - S0736-5748(13)00107-X [pii]
AID - 10.1016/j.ijdevneu.2013.06.010 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2013 Nov;31(7):580-5. doi: 10.1016/j.ijdevneu.2013.06.010. 
      Epub 2013 Jul 10.