PMID- 2385319
OWN - NLM
STAT- MEDLINE
DCOM- 19900917
LR  - 20061115
IS  - 0301-2603 (Print)
IS  - 0301-2603 (Linking)
VI  - 18
IP  - 5
DP  - 1990 May
TI  - [Disturbance of CSF absorption after experimental subarachnoid hemorrhage; 
      correlation with subarachnoid fibrosis].
PG  - 439-45
AB  - Correlation between subarachnoid fibrosis and absorption resistance of 
      cerebrospinal fluid (CSF) after experimental subarachnoid hemorrhage (SAH) was 
      studied in dogs. Scanning electron microscope (SEM) was used along with 
      steady-state infusion method. Experimental SAHs were produced by injecting 
      0.6-1.0 ml/kg of blood into the cisterna magna singly, twice and three times for 
      11, 7 and 8 dogs respectively. All dogs were sacrificed by perfusing their brain 
      with 10% formaldehyde solution immediately after completion of the measurement of 
      CSF absorption resistance. This was conducted at various periods ranging from 3 
      to 7 weeks after the first blood injection. Measurement of absorption resistance 
      was performed by infusion of physiological saline solution into the spinal 
      subarachnoid space at speeds of 0.1, 0.2 and 0.3 ml/min for 30, 15 and 10 minutes 
      respectively. The measurement was also conducted in 9 dogs without producing SAH 
      as a control study. Specimens collected from basal cistern, lateral cerebral 
      fissures and parasagittal sulci were observed in their subarachnoid spaces under 
      SEM, and the degree of subarachnoid fibrosis was expressed by one of 5 grades for 
      comparison with the absorption resistance in each dog. The grade of subarachnoid 
      fibrosis significantly correlated with the absorption resistance. The absorption 
      disturbances tended to improve after about a month along with disappearance of 
      subarachnoid fibrosis. The results in this study suggest that subarachnoid 
      fibrosis might be involved in inducing CSF absorption disturbances by affecting 
      both the major and the lesser pathways of CSF.
FAU - Okabe, S
AU  - Okabe S
AD  - Department of Neurosurgery, Hirosaki University School of Medicine, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - No Shinkei Geka
JT  - No shinkei geka. Neurological surgery
JID - 0377015
SB  - IM
MH  - Absorption
MH  - Animals
MH  - Cerebrospinal Fluid Pressure
MH  - Dogs
MH  - Fibrosis
MH  - Microscopy, Electron, Scanning
MH  - Subarachnoid Hemorrhage/*cerebrospinal fluid/pathology
MH  - Subarachnoid Space/*pathology
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
PST - ppublish
SO  - No Shinkei Geka. 1990 May;18(5):439-45.